Xinhe Xue
Overview
Explore the profile of Xinhe Xue including associated specialties, affiliations and a list of published articles.
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Articles
9
Citations
1163
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0
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Recent Articles
1.
Xue X, Gajic Z, Caragine C, Legut M, Walker C, Kim J, et al.
bioRxiv
. 2024 Dec;
PMID: 39651170
Recent massively-parallel approaches to decipher gene regulatory circuits have focused on the discovery of either -regulatory elements (CREs) or -acting factors. Here, we develop a scalable approach that pairs -...
2.
Yan R, Corman A, Katgara L, Wang X, Xue X, Gajic Z, et al.
Nat Biotechnol
. 2024 Nov;
PMID: 39572737
Pooled single-cell CRISPR screens have profiled either gene expression or chromatin accessibility but not both modalities. Here we develop MultiPerturb-seq, a high-throughput CRISPR screening platform with joint single-nucleus chromatin accessibility,...
3.
Yang X, Wang Z, Niu J, Zhai R, Xue X, Wu G, et al.
Microbiome
. 2023 Mar;
11(1):62.
PMID: 36978130
Background: Dysbiotic gut microbiome, genetically predisposed or chemically disrupted, has been linked with insulin-dependent diabetes (IDD) including autoimmune type 1 diabetes (T1D) in both humans and animal models. However, specific...
4.
Legut M, Gajic Z, Guarino M, Daniloski Z, Rahman J, Xue X, et al.
Nature
. 2022 Mar;
603(7902):728-735.
PMID: 35296855
The engineering of autologous patient T cells for adoptive cell therapies has revolutionized the treatment of several types of cancer. However, further improvements are needed to increase response and cure...
5.
Legut M, Daniloski Z, Xue X, McKenzie D, Guo X, Wessels H, et al.
Cell Rep
. 2020 Mar;
30(9):2859-2868.e5.
PMID: 32130891
A key limitation of the widely used CRISPR enzyme S. pyogenes Cas9 is the strict requirement of an NGG protospacer-adjacent motif (PAM) at the target site. This constraint can be...
6.
Zhang L, Xue X, Zhai R, Yang X, Li H, Zhao L, et al.
mSystems
. 2019 Dec;
4(6).
PMID: 31796564
Calorie restriction (CR) is accompanied by self-imposed daily restriction of food intake and an extended fasting period between meals. The impact of restricting feeding to the dark or light phase...
7.
Zhai R, Xue X, Zhang L, Yang X, Zhao L, Zhang C
Front Cell Infect Microbiol
. 2019 Jul;
9:239.
PMID: 31334133
is potential probiotic in that its type strain ATCC BAA-835 has beneficial effects upon obesity and diabetes. However, whether can improve inflammatory bowel diseases (IBD), which is a form of...
8.
Wang R, Li H, Yang X, Xue X, Deng L, Shen J, et al.
Front Microbiol
. 2018 Aug;
9:1602.
PMID: 30079055
Dysbiotic gut microbiota contributes to genetically obese phenotype in human. However, the effect of genetic obesity-associated gut microbiota on host hepatic metabolic deteriorations remains largely unknown. Gut microbiota from a...
9.
Zhao L, Zhang F, Ding X, Wu G, Lam Y, Wang X, et al.
Science
. 2018 Mar;
359(6380):1151-1156.
PMID: 29590046
The gut microbiota benefits humans via short-chain fatty acid (SCFA) production from carbohydrate fermentation, and deficiency in SCFA production is associated with type 2 diabetes mellitus (T2DM). We conducted a...