Xingfan Huang
Overview
Explore the profile of Xingfan Huang including associated specialties, affiliations and a list of published articles.
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14
Citations
3613
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Recent Articles
1.
Qiu C, Martin B, Welsh I, Daza R, Le T, Huang X, et al.
Nature
. 2024 Feb;
626(8001):1084-1093.
PMID: 38355799
The house mouse (Mus musculus) is an exceptional model system, combining genetic tractability with close evolutionary affinity to humans. Mouse gestation lasts only 3 weeks, during which the genome orchestrates...
2.
Huang X, Henck J, Qiu C, Sreenivasan V, Balachandran S, Amarie O, et al.
Nature
. 2023 Nov;
623(7988):772-781.
PMID: 37968388
Mouse models are a critical tool for studying human diseases, particularly developmental disorders. However, conventional approaches for phenotyping may fail to detect subtle defects throughout the developing mouse. Here we...
3.
Chiou K, Huang X, Bohlen M, Tremblay S, DeCasien A, ODay D, et al.
Sci Adv
. 2023 Oct;
9(41):eadh1914.
PMID: 37824616
Cataloging the diverse cellular architecture of the primate brain is crucial for understanding cognition, behavior, and disease in humans. Here, we generated a brain-wide single-cell multimodal molecular atlas of the...
4.
Qiu C, Martin B, Welsh I, Daza R, Le T, Huang X, et al.
bioRxiv
. 2023 Apr;
PMID: 37066300
The house mouse, , is an exceptional model system, combining genetic tractability with close homology to human biology. Gestation in mouse development lasts just under three weeks, a period during...
5.
Calderon D, Blecher-Gonen R, Huang X, Secchia S, Kentro J, Daza R, et al.
Science
. 2022 Aug;
377(6606):eabn5800.
PMID: 35926038
is a powerful, long-standing model for metazoan development and gene regulation. We profiled chromatin accessibility in almost 1 million and gene expression in half a million nuclei from overlapping windows...
6.
Qiu C, Cao J, Martin B, Li T, Welsh I, Srivatsan S, et al.
Nat Genet
. 2022 Mar;
54(3):328-341.
PMID: 35288709
Mammalian embryogenesis is characterized by rapid cellular proliferation and diversification. Within a few weeks, a single-cell zygote gives rise to millions of cells expressing a panoply of molecular programs. Although...
7.
Zhang X, Jeong M, Huang X, Wang X, Wang X, Zhou W, et al.
Mol Cell
. 2020 May;
78(3):506-521.e6.
PMID: 32386543
Higher-order chromatin structure and DNA methylation are implicated in multiple developmental processes, but their relationship to cell state is unknown. Here, we find that large (>7.3 kb) DNA methylation nadirs...
8.
Wutz G, Ladurner R, St Hilaire B, Stocsits R, Nagasaka K, Pignard B, et al.
Elife
. 2020 Feb;
9.
PMID: 32065581
Eukaryotic genomes are folded into loops. It is thought that these are formed by cohesin complexes extrusion, either until loop expansion is arrested by CTCF or until cohesin is removed...
9.
Cao J, Spielmann M, Qiu X, Huang X, Ibrahim D, Hill A, et al.
Nature
. 2019 Feb;
566(7745):496-502.
PMID: 30787437
Mammalian organogenesis is a remarkable process. Within a short timeframe, the cells of the three germ layers transform into an embryo that includes most of the major internal and external...
10.
Lee D, Tan W, Anene-Nzelu C, Lee C, Li P, Luu T, et al.
Circulation
. 2019 Feb;
139(16):1937-1956.
PMID: 30717603
Background: The human genome folds in 3 dimensions to form thousands of chromatin loops inside the nucleus, encasing genes and cis-regulatory elements for accurate gene expression control. Physical tethers of...