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Xin Maizie Zhou

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Articles 11
Citations 15
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Recent Articles
1.
Xu K, Xu Y, Wang Z, Zhou X, Zhang L
Genome Biol . 2025 Feb; 26(1):34. PMID: 39980033
Spatially resolved transcriptomics (SRT) data provide critical insights into gene expression patterns within tissue contexts, necessitating effective methods for identifying spatial domains. We introduce stDyer, an end-to-end deep learning framework...
2.
Potu T, Hu Y, Khan R, Dharani S, Ni J, Zhang L, et al.
bioRxiv . 2025 Feb; PMID: 39975167
Intra-tumor heterogeneity (ITH) is a compounding factor for cancer prognosis and treatment. Single-cell DNA sequencing (scDNA-seq) provides cellular resolution of the variations in a cell and has been widely used...
3.
Zhu J, Garin C, Qi X, Machado A, Wang Z, Hamed S, et al.
bioRxiv . 2024 Sep; PMID: 39229176
Cognitive abilities of primates, including humans, continue to improve through adolescence . While a range of changes in brain structure and connectivity have been documented , how they affect neuronal...
4.
Zhu J, Zhou X, Constantinidis C, Salinas E, Stanford T
iScience . 2024 Aug; 27(8):110488. PMID: 39156644
The ability to suppress inappropriate actions and respond rapidly to appropriate ones matures late in life, after puberty. We investigated the development of this capability in monkeys trained to look...
5.
Luo C, Liu Y, Zhou X
Nat Commun . 2024 Aug; 15(1):6956. PMID: 39138168
Structural variants (SVs) significantly contribute to human genome diversity and play a crucial role in precision medicine. Although advancements in single-molecule long-read sequencing offer a groundbreaking resource for SV detection,...
6.
Hu Y, Xie M, Li Y, Rao M, Shen W, Luo C, et al.
Genome Biol . 2024 Aug; 25(1):212. PMID: 39123269
Background: Spatial transcriptomics (ST) is advancing our understanding of complex tissues and organisms. However, building a robust clustering algorithm to define spatially coherent regions in a single tissue slice and...
7.
Zhang L, Zhou X, Mallory X
Bioinformatics . 2024 Jul; PMID: 39067018
Motivation: Copy number alterations (CNAs) play an important role in disease progression, especially in cancer. Single-cell DNA sequencing (scDNA-seq) facilitates the detection of CNAs of each cell that is sequenced...
8.
Shen W, Liu C, Hu Y, Lei Y, Wong H, Wu S, et al.
bioRxiv . 2024 Apr; PMID: 38645128
A main limitation of bulk transcriptomic technologies is that individual measurements normally contain contributions from multiple cell populations, impeding the identification of cellular heterogeneity within diseased tissues. To extract cellular...
9.
Liu Y, Luo C, Golding S, Ioffe J, Zhou X
Nat Commun . 2024 Mar; 15(1):2447. PMID: 38503752
Long-read sequencing offers long contiguous DNA fragments, facilitating diploid genome assembly and structural variant (SV) detection. Efficient and robust algorithms for SV identification are crucial with increasing data availability. Alignment-based...
10.
Veldsman W, Zhou X, Zhang Y, Li B, Zhang L
Front Genet . 2023 Sep; 14:1280648. PMID: 37745841
No abstract available.