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Xikun Liu

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Articles 18
Citations 86
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Recent Articles
1.
Shi W, Li Z, Wang W, Liu X, Wu H, Chen X, et al.
J Pharm Anal . 2024 Apr; 14(4):100931. PMID: 38655401
Dynamic changes in gut dysbiosis and metabolomic dysregulation are associated with immune-complex glomerulonephritis (ICGN). However, an in-depth study on this topic is currently lacking. Herein, we report an ICGN model...
2.
Chen Y, Liu X, Ma J, Wang W, Li Z, Wu H, et al.
J Ethnopharmacol . 2024 Apr; 329:118156. PMID: 38583729
Ethnopharmacological Relevance: Throughout Chinese history, Hydrangea paniculata Siebold has been utilized as a traditional medicinal herb to treat a variety of ailments associated to inflammation. In a number of immune-mediated...
3.
Zhan X, Liu X, Rang L, Shen M, Zhang J, Tang R, et al.
Clin Chim Acta . 2023 Dec; 553:117707. PMID: 38103853
Lenalidomide is the first-line drug for the clinical treatment of multiple myeloma. However, its efficacy differs significantly among patients. Clinically, after lenalidomide treatment, few patients' conditions worsened, whereas others remained...
4.
Liu X, Duan S, Jin Y, Walker E, Tsao M, Jang J, et al.
ACS Chem Neurosci . 2023 Dec; 14(24):4395-4408. PMID: 38050862
Abnormal cytosolic aggregation of TAR DNA-binding protein of 43 kDa (TDP-43) is observed in multiple diseases, including amyotrophic lateral sclerosis (ALS), frontotemporal lobar degeneration, and Alzheimer's disease. Previous studies have...
5.
Li Z, Zhang X, Wu H, Ma Z, Liu X, Ma J, et al.
Commun Biol . 2023 Nov; 6(1):1189. PMID: 37993541
Coumarins isolated from Hydrangea paniculata (HP) had a renal protective effect in experimental membranous nephritis (MN), but the mechanisms are not clear. Currently, we investigate whether the modulation of gut...
6.
Ingolfsson H, Rizuan A, Liu X, Mohanty P, Souza P, Marrink S, et al.
Biophys J . 2023 Oct; 122(22):4370-4381. PMID: 37853696
The RNA-binding protein TDP-43 is associated with mRNA processing and transport from the nucleus to the cytoplasm. TDP-43 localizes in the nucleus as well as accumulating in cytoplasmic condensates such...
7.
Balke-Want H, Keerthi V, Gkitsas N, Mancini A, Kurgan G, Fowler C, et al.
Mol Cancer . 2023 Jun; 22(1):100. PMID: 37365642
Background: Chimeric Antigen Receptor (CAR) T cells are now standard of care (SOC) for some patients with B cell and plasma cell malignancies and could disrupt the therapeutic landscape of...
8.
Wu H, Shi X, Zang Y, Zhao X, Liu X, Wang W, et al.
Life Sci . 2023 Jun; 327:121864. PMID: 37336359
Aims: Cisplatin is a widely-used drug in the clinical treatment of tumors, but kidney nephrotoxicity is one of the reasons that limits its widespread use. We previously found that 7-hydroxycoumarin-β-D-glucuronide...
9.
Arsiccio A, Liu X, Ganguly P, Buratto S, Bowers M, Shea J
J Phys Chem B . 2023 May; 127(18):4022-4031. PMID: 37129599
The intrinsically disordered protein Tau represents the main component of neurofibrillary tangles that are a hallmark of Alzheimer's disease. A small fragment of Tau, known as paired helical filament 6...
10.
Liu X, Ganguly P, Jin Y, Jhatro M, Shea J, Buratto S, et al.
J Am Chem Soc . 2022 Aug; 144(32):14614-14626. PMID: 35917596
Amyloid β (Aβ) protein is responsible for Alzheimer's disease, and one of its important fragments, Aβ(25-35), is found in the brain and has been shown to be neurotoxic. Tachykinin neuropeptides,...