Xiaomi Chen
Overview
Explore the profile of Xiaomi Chen including associated specialties, affiliations and a list of published articles.
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12
Citations
320
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Recent Articles
1.
Terhune E, Cuevas M, Monley A, Wethey C, Chen X, Cattell M, et al.
Hum Mutat
. 2020 Dec;
42(4):392-407.
PMID: 33382518
Idiopathic scoliosis (IS) is a spinal disorder affecting up to 3% of otherwise healthy children. IS has a strong familial genetic component and is believed to be genetically complex due...
2.
Kogut I, McCarthy S, Pavlova M, Astling D, Chen X, Jakimenko A, et al.
Nat Commun
. 2018 Feb;
9(1):745.
PMID: 29467427
Induced pluripotent stem cells (iPSCs) hold great promise for regenerative medicine; however, their potential clinical application is hampered by the low efficiency of somatic cell reprogramming. Here, we show that...
3.
Cohrs R, Lee K, Beach A, Sanford B, Baird N, Como C, et al.
J Virol
. 2017 Jul;
91(20).
PMID: 28747504
The neurotropic herpesvirus varicella-zoster virus (VZV) establishes a lifelong latent infection in humans following primary infection. The low abundance of VZV nucleic acids in human neurons has hindered an understanding...
4.
Chen Z, Eder M, Elos M, Viboolsittiseri S, Chen X, Wang J
J Immunol
. 2016 Jan;
196(5):2335-47.
PMID: 26810227
Activation-induced deaminase (AID) functions by deaminating cytosines and causing U:G mismatches, a rate-limiting step of Ab gene diversification. However, precise mechanisms regulating AID deamination frequency remain incompletely understood. Moreover, it...
5.
Chen Z, Getahun A, Chen X, Dollin Y, Cambier J, Wang J
J Immunol
. 2015 Oct;
195(11):5461-5471.
PMID: 26500350
Class switch recombination (CSR) generates isotype-switched Abs with distinct effector functions. B cells express phosphatase and tensin homolog (PTEN) and multiple isoforms of class IA PI3K catalytic subunits, including p110α...
6.
Chen Z, Ranganath S, Viboolsittiseri S, Eder M, Chen X, Elos M, et al.
J Immunol
. 2015 Jan;
194(3):1383.
PMID: 25596302
No abstract available.
7.
Chen Z, Ranganath S, Viboolsittiseri S, Eder M, Chen X, Elos M, et al.
J Immunol
. 2014 Oct;
193(11):5545-56.
PMID: 25339658
Activation-induced deaminase (AID) initiates U:G mismatches, causing point mutations or DNA double-stranded breaks at Ig loci. How AID-initiated lesions are prevented from inducing genome-wide damage remains elusive. A differential DNA...
8.
Chen X, Liu G, Leffak M
Nucleic Acids Res
. 2013 May;
41(13):6460-74.
PMID: 23658226
The specification of mammalian chromosomal replication origins is incompletely understood. To analyze the assembly and activation of prereplicative complexes (pre-RCs), we tested the effects of tethered binding of chromatin acetyltransferases...
9.
Liu G, Chen X, Leffak M
Mol Cell Biol
. 2012 Nov;
33(3):571-81.
PMID: 23166299
(CTG)(n) · (CAG)(n) trinucleotide repeat (TNR) expansion in the 3' untranslated region of the dystrophia myotonica protein kinase (DMPK) gene causes myotonic dystrophy type 1. However, a direct link between...
10.
Liu G, Myers S, Chen X, Bissler J, Sinden R, Leffak M
J Biol Chem
. 2012 Aug;
287(40):33412-23.
PMID: 22872635
DNA sequences prone to forming noncanonical structures (hairpins, triplexes, G-quadruplexes) cause DNA replication fork stalling, activate DNA damage responses, and represent hotspots of genomic instability associated with human disease. The...