Xiaojuan Chai
Overview
Explore the profile of Xiaojuan Chai including associated specialties, affiliations and a list of published articles.
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Articles
9
Citations
171
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0
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Recent Articles
1.
Yang Y, Chai X, Xin W, Wang D, Dai C, Qian F, et al.
FEBS Lett
. 2021 Apr;
595(11):1587-1603.
PMID: 33792041
OX40 is a costimulatory molecule that belongs to the tumor necrosis factor receptor (TNFR) superfamily. OX40 agonist-based combinations are emerging as promising candidates for novel cancer immunotherapy. Clinical trials have...
2.
Hu B, Li Y, Gao L, Guo Y, Zhang Y, Chai X, et al.
Am J Pathol
. 2017 Mar;
187(5):1059-1067.
PMID: 28279656
Sepsis is defined as the host's deleterious systemic inflammatory response to microbial infections. Herein, we report an essential role of the fatty acid binding protein 4 (FABP4; alias adipocyte protein...
3.
Chai X, Guo Y, Jiang M, Hu B, Li Z, Fan J, et al.
Nat Commun
. 2015 Aug;
6:7979.
PMID: 26259151
Sepsis is the host's deleterious systemic inflammatory response to microbial infections. Here we report an essential role for the oestrogen sulfotransferase (EST or SULT1E1), a conjugating enzyme that sulfonates and...
4.
Wang Y, Chai S, Lin W, Chai X, Elias A, Wu J, et al.
Biochem Pharmacol
. 2015 Jun;
96(4):357-68.
PMID: 26119819
The human pregnane X receptor (hPXR), a member of the nuclear receptor superfamily, senses xenobiotics and controls the transcription of genes encoding drug-metabolizing enzymes and transporters. The regulation of hPXR's...
5.
Chai X, Zeng S, Xie W
Expert Opin Drug Metab Toxicol
. 2013 Jan;
9(3):253-66.
PMID: 23327618
Introduction: 'Orphan' nuclear receptors belong to the nuclear receptor (NR) superfamily of transcriptional factors. Binding of ligands to these receptors results in the recruitment of the co-activators, thereby regulating the...
6.
Wada T, Ihunnah C, Gao J, Chai X, Zeng S, Philips B, et al.
Mol Endocrinol
. 2011 Aug;
25(9):1612-23.
PMID: 21816900
The estrogen sulfotransferase (EST) is a phase II drug-metabolizing enzyme known to catalyze the sulfoconjugation of estrogens. EST is highly expressed in the white adipose tissue of male mice, but...
7.
Yu C, Chai X, Yu L, Chen S, Zeng S
J Ethnopharmacol
. 2011 Apr;
136(1):137-43.
PMID: 21524698
Aim Of The Study: To investigate the ability of traditional Chinese medicines (TCMs) and their bioactive compounds to activate pregnane X receptor (PXR) signalling pathway. Materials And Methods: We screened...
8.
Zhang X, Yao Y, Lou Y, Jiang H, Wang X, Chai X, et al.
Drug Metab Dispos
. 2010 Sep;
38(12):2157-65.
PMID: 20837661
Ebracteolata compound B (ECB) is one major active component of both Euphorbia ebracteolata and Euphorbia fischeriana, which have been extensively used as a tuberculocide in the Asian countries. The aim...
9.
Shen S, Zhang F, Zeng S, Tian Y, Chai X, Gee S, et al.
Anal Chem
. 2009 Feb;
81(7):2668-77.
PMID: 19245253
Styrene has been reported to be pneumotoxic and hepatotoxic in humans and animals. Styrene oxide, a major reactive metabolite of styrene, has been found to form covalent binding with proteins,...