Xiaohong Huo
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Explore the profile of Xiaohong Huo including associated specialties, affiliations and a list of published articles.
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33
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343
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Recent Articles
11.
Huo X, Li G, Wang X, Zhang W
Angew Chem Int Ed Engl
. 2022 Aug;
61(45):e202210086.
PMID: 35916079
Bimetallic catalysis has emerged as an efficient strategy for the development of new chemical reactions. Importantly, this strategy also provides a simple and powerful platform for stereodivergent synthesis, whereby all...
12.
Peng Y, Han C, Luo Y, Li G, Huo X, Zhang W
Angew Chem Int Ed Engl
. 2022 Mar;
61(23):e202203448.
PMID: 35319811
The first asymmetric Ni/Cu cocatalyzed benzylation of aldimine esters is reported. A series of benzyl-substituted α-quaternary amino acids could be synthesized in high yield and with high levels of enantioselectivity...
13.
Li G, Zhao L, Luo Y, Peng Y, Xu K, Huo X, et al.
Chemistry
. 2022 Mar;
28(24):e202200273.
PMID: 35262998
Asymmetric desymmetrization has been demonstrated to be a powerful strategy for building stereocenters in asymmetric synthesis. Herein, a Pd/Cu catalyzed asymmetric desymmetrization reaction with a simple geminal dicarboxylate is reported....
14.
Wang M, Zhang L, Huo X, Zhang Z, Zhang W
Curr Protoc
. 2021 Dec;
1(12):e303.
PMID: 34878730
Remdesivir has become an important compound for the treatment of COVID-19. Here, we describe the catalytic asymmetric synthesis of this anti-COVID-19 drug. First, the P-racemic phosphoryl chloride is synthesized in...
15.
Peng Y, Huo X, Luo Y, Wu L, Zhang W
Angew Chem Int Ed Engl
. 2021 Sep;
60(47):24941-24949.
PMID: 34532948
The development of efficient and straightforward methods for obtaining all optically active isomers of structurally rigid spirocycles from readily available starting materials is of great value in drug discovery and...
16.
Zhang J, Huo X, Xiao J, Zhao L, Ma S, Zhang W
J Am Chem Soc
. 2021 Aug;
143(32):12622-12632.
PMID: 34351136
In contrast to the widely explored methods for the asymmetric synthesis of molecules bearing a single stereocenter or adjacent stereocenters, the concurrent construction of 1,3-stereogenic centers in an enantio- and...
17.
Wang T, Peng Y, Li G, Luo Y, Ye Y, Huo X, et al.
Chemistry
. 2021 May;
27(40):10255-10260.
PMID: 33982366
3,3-Disubstituted oxindoles bearing quaternary and tertiary stereogenic centers are privileged structural motifs, which widely exist in pharmaceutical and natural products. Herein, a highly regio-, enantio-, and diastereoselective allylic alkylation of...
18.
Zhao L, Li G, He R, Liu P, Wang F, Huo X, et al.
Org Biomol Chem
. 2021 Feb;
19(9):1955-1959.
PMID: 33599240
We report a stereodivergent Pd/Cu catalyst system that was successfully applied to the asymmetric allylic alkylation of symmetrical 1,3-disubstituted allyl acetates with prochiral imino esters, providing efficient access to enantiopure...
19.
Wang M, Zhang L, Huo X, Zhang Z, Yuan Q, Li P, et al.
Angew Chem Int Ed Engl
. 2020 Sep;
59(47):20814-20819.
PMID: 32870563
The catalytic asymmetric synthesis of the anti-COVID-19 drug Remdesivir has been realized by the coupling of the P-racemic phosphoryl chloride with protected nucleoside GS441524. The chiral bicyclic imidazole catalyst used...
20.
He R, Huo X, Zhao L, Wang F, Jiang L, Liao J, et al.
J Am Chem Soc
. 2020 Apr;
142(18):8097-8103.
PMID: 32307983
A stereodivergent Pd/Cu catalyst system has been developed for the unprecedented dynamic kinetic asymmetric transformation (DyKAT) of racemic unsymmetrical 1,3-disubstituted allylic acetates with prochiral aldimine esters. A series of α,α-disubstituted...