Xiaochun Yu
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Explore the profile of Xiaochun Yu including associated specialties, affiliations and a list of published articles.
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154
Citations
6481
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Recent Articles
1.
Luo M, Yu X
Proc Natl Acad Sci U S A
. 2025 Mar;
122(11):e2422029122.
PMID: 40067889
Mutations in the gene result in Nijmegen breakage syndrome (NBS), and the gene encodes NBS1 that forms a complex with MRE11 and RAD50 and participates in DNA damage repair. However,...
2.
Li P, Wu D, Yu X
DNA Repair (Amst)
. 2025 Mar;
148:103824.
PMID: 40056493
Poly(ADP-ribosyl)ation (PARylation), a reversible post-translational modification mediated by poly(ADP-ribose) polymerases (PARPs), plays crucial roles in DNA replication and DNA damage repair. Since interfering PARylation induces selective cytotoxicity in tumor cells...
3.
Zhang M, Liu T, Chen X, Jin H, Lv J, Wang S, et al.
Org Biomol Chem
. 2025 Feb;
23(10):2323-2357.
PMID: 39932496
In recent years, significant achievements have been made in the field of electroorganic chemistry regarding the difunctionalization of alkenes. Researchers have developed innovative strategies utilizing the unique reactivity of electrochemical...
4.
Ouyang Z, Wang Q, Li X, Dai Q, Tang M, Shao L, et al.
Nat Methods
. 2024 Dec;
22(2):335-347.
PMID: 39715887
Three-dimensional structured illumination microscopy (3D-SIM) provides excellent optical sectioning and doubles the resolution in all dimensions compared with wide-field microscopy. However, its much lower axial resolution results in blurred fine...
5.
Liu J, Li Q, Hu Y, Yu Y, Zheng K, Li D, et al.
Science
. 2024 Dec;
386(6726):1141-1146.
PMID: 39636971
The current reference genome of , GRCm39, has major gaps in both euchromatic and heterochromatic regions associated with repetitive sequences. In this work, we have sequenced and assembled the telomere-to-telomere...
6.
Kassab M, Chen Y, Wang X, He B, Brown E, Yu X
BMC Biol
. 2024 Jul;
22(1):151.
PMID: 38977974
Background: RNA-DNA hybrids or R-loops are associated with deleterious genomic instability and protective immunoglobulin class switch recombination (CSR). However, the underlying phenomenon regulating the two contrasting functions of R-loops is...
7.
Li P, Yu X
DNA Repair (Amst)
. 2024 May;
139:103692.
PMID: 38759435
Over the past few decades, unbiased approaches such as genetic screening and protein affinity purification have unveiled numerous proteins involved in DNA double-strand break (DSB) repair and maintaining genome stability....
8.
Li P, Gai X, Li Q, Yang Q, Yu X
Nucleic Acids Res
. 2024 Apr;
52(11):6360-6375.
PMID: 38682589
Although DNA-PK inhibitors (DNA-PK-i) have been applied in clinical trials for cancer treatment, the biomarkers and mechanism of action of DNA-PK-i in tumor cell suppression remain unclear. Here, we observed...
9.
Chen L, Gai X, Yu X
J Biol Chem
. 2024 Feb;
300(3):107115.
PMID: 38403248
RAD51-associated protein 1 (RAD51AP1) is known to promote homologous recombination (HR) repair. However, the precise mechanism of RAD51AP1 in HR repair is unclear. Here, we identify that RAD51AP1 associates with...
10.
Wu Y, Chen Y, Yu X, Zhang M, Li Z
Int J Mol Sci
. 2024 Jan;
25(1).
PMID: 38203614
The elevated occurrence of debilitating neurodegenerative disorders, such as amyotrophic lateral sclerosis (ALS), Huntington's disease (HD), Alzheimer's disease (AD), Parkinson's disease (PD) and Machado-Joseph disease (MJD), demands urgent disease-modifying therapeutics....