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Xiao R Huang

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Articles 44
Citations 3086
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Recent Articles
1.
Wang W, Chen J, Hu D, Pan P, Liang L, Wu W, et al.
Adv Sci (Weinh) . 2021 Nov; 9(3):e2103248. PMID: 34813685
COVID-19 is infected by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and can cause severe multiple organ injury and death. Kidney is one of major target organs of COVID-19 and...
2.
Wu W, Huang X, You Y, Xue L, Wang X, Meng X, et al.
Int J Biol Sci . 2021 Sep; 17(13):3583-3594. PMID: 34512167
TGF-β1 has long been considered as a key mediator in diabetic kidney disease (DKD) but anti-TGF-β1 treatment fails clinically, suggesting a diverse role for TGF-β1 in DKD. In the present...
3.
Li J, Tang Y, Lv J, Wang X, Yang H, Tang P, et al.
J Cell Mol Med . 2019 Apr; 23(6):3867-3877. PMID: 30968541
Macrophage migration inhibitory factor (MIF) is pleiotropic cytokine that has multiple effects in many inflammatory and immune diseases. This study reveals a potential role of MIF in acute kidney injury...
4.
Sun S, Tang P, Feng M, Xiao J, Huang X, Li P, et al.
Diabetes . 2017 Dec; 67(4):731-744. PMID: 29222368
Transforming growth factor-β/Smad signaling plays an important role in diabetic nephropathy. The current study identified a novel Smad3-dependent long noncoding RNA (lncRNA) Erbb4-IR in the development of type 2 diabetic...
5.
Fu S, Tang Y, Huang X, Feng M, Xu A, Lan H
Clin Sci (Lond) . 2017 Jun; 131(15):1955-1969. PMID: 28566468
Smad7 plays a protective role in chronic kidney disease; however, its role in acute kidney injury (AKI) remains unexplored. Here, we report that Smad7 protects against AKI by rescuing the...
6.
Lai W, Tang Y, Huang X, Tang P, Xu A, Szalai A, et al.
Kidney Int . 2016 Jul; 90(3):610-26. PMID: 27470679
Acute kidney injury (AKI) is exacerbated in C-reactive protein transgenic mice but alleviated in Smad3 knockout mice. Here we used C-reactive protein transgenic/Smad3 wild-type and C-reactive protein transgenic/Smad3 knockout mice...
7.
Dai X, Huang X, Zhou L, Zhang L, Fu P, Manthey C, et al.
Oncotarget . 2016 Feb; 7(10):10841-56. PMID: 26909597
Aristolochic acid nephropathy (AAN) is a progressive kidney disease caused by some Chinese herbal medicines, but treatment remains ineffective. Macrophage accumulation is an early feature in human and experimental AAN;...
8.
Zhou Q, Xiong Y, Huang X, Tang P, Yu X, Lan H
Sci Rep . 2015 Dec; 5:17901. PMID: 26648110
Transforming growth factor-β/Smad3 signaling plays a critical role in the process of chronic kidney disease (CKD), but targeting Smad3 systematically may cause autoimmune disease by impairing immunity. In this study,...
9.
Zhou Q, Huang X, Yu J, Yu X, Lan H
Mol Ther . 2015 Mar; 23(6):1034-1043. PMID: 25743111
Increasing evidence shows that microRNAs play an important role in kidney disease. However, functions of long noncoding RNAs (lncRNAs) in kidney diseases remain undefined. We have previously shown that TGF-β1...
10.
Liu G, Li Y, Huang X, Wei L, Zhang Y, Feng M, et al.
Clin Sci (Lond) . 2014 Feb; 127(3):195-208. PMID: 24511990
The TGFβ (transforming growth factor β)/SMAD and NF-κB (nuclear factor κB) signalling pathways play a key role in hypertensive nephropathy. The present study examined whether targeting these pathways by SMAD7,...