Xiao-Ran Han
Overview
Explore the profile of Xiao-Ran Han including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
9
Citations
514
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
ALK fusion promotes metabolic reprogramming of cancer cells by transcriptionally upregulating PFKFB3
Hu M, Bao R, Lin M, Han X, Ai Y, Gao Y, et al.
Oncogene
. 2022 Sep;
41(40):4547-4559.
PMID: 36064579
Anaplastic lymphoma kinase (ALK), a receptor tyrosine kinase of the insulin receptor kinase subfamily, is activated in multiple cancer types through translocation or overexpression. Although several generations of ALK tyrosine...
2.
Han X, Sasaki N, Jackson S, Wang P, Li Z, Smith M, et al.
Sci Adv
. 2020 Dec;
6(51).
PMID: 33355139
Evolutionarily conserved DCAF1 is a major substrate receptor for the DDB1-CUL4-ROC1 E3 ubiquitin ligase (CRL4) and controls cell proliferation and development. The molecular basis for these functions is unclear. We...
3.
Chen L, Chen Y, Zhang C, Jiao B, Liang S, Tan Q, et al.
J Med Chem
. 2020 Oct;
63(23):14562-14575.
PMID: 33058680
We report compounds (CG416) and (CG428) as two first-in-class tropomyosin receptor kinase (TRK) degraders that target the intracellular kinase domain of TRK. Degraders and reduced levels of the tropomyosin 3...
4.
Han X, Chen L, Wei Y, Yu W, Chen Y, Zhang C, et al.
J Med Chem
. 2020 Apr;
63(8):4069-4080.
PMID: 32223235
BRAF is among the most frequently mutated oncogenes in human cancers. Multiple small molecule BRAF kinase inhibitors have been approved for treating melanoma carrying BRAF-V600 mutations. However, the benefits of...
5.
Electrochemical Synthesis of α-Ketoamides under Catalyst-, Oxidant-, and Electrolyte-Free Conditions
Chen J, Wu H, Gui Q, Han X, Wu Y, Du K, et al.
Org Lett
. 2020 Mar;
22(6):2206-2209.
PMID: 32124611
A catalyst-, oxidant-, electrolyte-free method for the preparation of α-ketoamides through the direct electrochemical amidation of α-ketoaldehydes and amines with innocuous hydrogen as the sole byproduct at ambient temperature was...
6.
Fan Y, Guo T, Han X, Liu J, Cai Y, Xue H, et al.
EBioMedicine
. 2019 Jul;
45:393-407.
PMID: 31303501
Background: Recent studies have revealed that vitamin D deficiency may increase the risk of Alzheimer's disease, and vitamin D supplementation may be effective strategy to ameliorate the neurodegenerative process in...
7.
Zhang C, Han X, Yang X, Jiang B, Liu J, Xiong Y, et al.
Eur J Med Chem
. 2018 Apr;
151:304-314.
PMID: 29627725
Anaplastic lymphoma kinase (ALK) activation has been associated with many types of human cancer. Significant efforts have been devoted to the development of ALK inhibitors to antagonize the kinase activity...
8.
Zhang Y, Yuan J, Wang K, Fu X, Han X, Threapleton D, et al.
Oncotarget
. 2016 Oct;
7(48):78985-78993.
PMID: 27738317
Objectives: Estimate the epidermal growth factor receptor (EGFR) mutation prevalence in all non-small cell lung cancer (NSCLC) patients and patient subgroups. Results: A total of 456 studies were included, reporting...
9.
Hypertension-associated C825T polymorphism impairs the function of Gβ3 to target GRK2 ubiquitination
Zha Z, Han X, Smith M, Lei Q, Guan K, Xiong Y
Cell Discov
. 2016 Jul;
2:16005.
PMID: 27462452
Population-based and case-control studies in different ethnicities have linked a polymorphism, C825T, in exon 10 of GNB3 gene to hypertension and several additional diseases. The 825T allele is associated with...