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Xiangru Huo

Explore the profile of Xiangru Huo including associated specialties, affiliations and a list of published articles. Areas
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Articles 6
Citations 156
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Recent Articles
1.
He J, Huo X, Pei G, Jia Z, Yan Y, Yu J, et al.
Cell . 2024 Apr; 187(11):2746-2766.e25. PMID: 38631355
Precise control of gene expression levels is essential for normal cell functions, yet how they are defined and tightly maintained, particularly at intermediate levels, remains elusive. Here, using a series...
2.
Yan Z, Ji L, Huo X, Wang Q, Zhang Y, Wen B
Genomics Proteomics Bioinformatics . 2020 Dec; 18(4):359-370. PMID: 33285284
In the nucleus, chromatin is folded into hierarchical architecture that is tightly linked to various nuclear functions. However, the underlying molecular mechanisms that confer these architectures remain incompletely understood. Here,...
3.
Ming H, Wang Q, Zhang Y, Ji L, Cheng L, Huo X, et al.
Protein Cell . 2020 Sep; 12(4):297-304. PMID: 32935279
No abstract available.
4.
Ji L, Huo X, Zhang Y, Yan Z, Wang Q, Wen B
Biochim Biophys Acta Gene Regul Mech . 2020 Mar; 1863(5):194518. PMID: 32113985
In the nucleus, chromosomes are hierarchically folded into active (A) and inactive (B) compartments composed of topologically associating domains (TADs). Genomic regions interact with nuclear lamina, termed lamina-associated domains (LADs)....
5.
Huo X, Ji L, Zhang Y, Lv P, Cao X, Wang Q, et al.
Mol Cell . 2019 Nov; 77(2):368-383.e7. PMID: 31677973
Interphase chromatin is hierarchically organized into higher-order architectures that are essential for gene functions, yet the biomolecules that regulate these 3D architectures remain poorly understood. Here, we show that scaffold...
6.
Fan H, Lv P, Huo X, Wu J, Wang Q, Cheng L, et al.
Genome Res . 2017 Dec; 28(2):192-202. PMID: 29273625
Eukaryotic chromosomes are folded into higher-order conformations to coordinate genome functions. In addition to long-range chromatin loops, recent chromosome conformation capture (3C)-based studies have indicated higher levels of chromatin structures...