Xianghan Zhang
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Explore the profile of Xianghan Zhang including associated specialties, affiliations and a list of published articles.
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Articles
32
Citations
168
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Recent Articles
1.
Xia Y, Su M, Ye Z, Du F, Wang X, Guan D, et al.
Trends Biotechnol
. 2025 Feb;
PMID: 39955233
Gene therapy is promising for treating genetic disorders, but faces challenges in treating cancer due to the intricate genetic and immunosuppressive landscape of this disease. Here, we describe a technology...
2.
Xia Y, Liu C, Zhao X, Wu K, Cao J, Cao Y, et al.
Mater Today Bio
. 2024 Dec;
29:101345.
PMID: 39649250
Natural enzyme-based catalytic cascades have garnered increasing attention in cancer therapy, but their clinical utility is greatly limited due to loss of function during delivery. Here, we developed an enzyme...
3.
Zhang X, Zhang H, Dong Q, Qin Y, Cao Y, Zhu H, et al.
Nano Lett
. 2024 Nov;
24(49):15817-15826.
PMID: 39584561
Hypoxia-induced tumor metastasis severely hinders the efficacy of photodynamic therapy (PDT) in cancer treatment. Current strategies predominantly offer palliative suppression of the HIF-1α pathway, emphasizing the urgent need for innovative...
4.
Li R, Liu Z, Xiong Y, Zhang X, Chen L, Li D, et al.
ACS Appl Mater Interfaces
. 2024 Nov;
16(46):63941-63950.
PMID: 39499087
Achieving rapid extraction and detection of analytical solutions from plant tissues to circumvent cumbersome procedures and reduce the dependence on detection instruments remains a challenge. Herein, a colorimetric microneedle integrated...
5.
Yang P, Liu S, Chen Z, Liu W, Duan D, Yang Z, et al.
J Nanobiotechnology
. 2024 Nov;
22(1):670.
PMID: 39487480
Background: Mn-mediated chemodynamic therapy (CDT) has been emerged as a promising cancer therapeutic modality that relies heavily on HCO level in the system. Although the physiological buffers (HCO/HCO) provide certain...
6.
Lv Y, Li J, Yu S, Zhang Y, Hu H, Sun K, et al.
J Biol Chem
. 2024 Feb;
300(3):105772.
PMID: 38382674
Pre-mRNA splicing is a precise regulated process and is crucial for system development and homeostasis maintenance. Mutations in spliceosomal components have been found in various hematopoietic malignancies (HMs) and have...
7.
Ning P, Du F, Wang H, Gong X, Xia Y, Zhang X, et al.
J Control Release
. 2024 Feb;
367:697-707.
PMID: 38331001
Precise targeting is a major prerequisite for effective cancer therapy because it ensures a sufficient therapeutic dosage in tumors while minimizing off-target side effects. Herein, we report a live-macrophage-based therapeutic...
8.
Xia Y, Wu K, Liu C, Zhao X, Wang J, Cao J, et al.
Adv Sci (Weinh)
. 2023 Dec;
11(10):e2305600.
PMID: 38152963
Despite the potential of protein therapeutics, the cytosolic delivery of proteins with high efficiency and bioactivity remains a significant challenge owing to exocytosis and lysosomal degradation after endocytosis. Therefore, it...
9.
Rao Z, Xia Y, Jia Q, Zhu Y, Wang L, Liu G, et al.
J Nanobiotechnology
. 2023 Aug;
21(1):265.
PMID: 37563614
Background: Emerging ferroptosis-driven therapies based on nanotechnology function either by increasing intracellular iron level or suppressing glutathione peroxidase 4 (GPX4) activity. Nevertheless, the therapeutic strategy of simultaneous iron delivery and...
10.
Tian Z, Liang S, Zhou X, Luo H, Tian M, Zhang X, et al.
Front Oncol
. 2022 Dec;
12:885036.
PMID: 36505820
Introduction: Positive resection margins occur in about 2.8%-8.2% gastric cancer surgeries and is associated with poor prognosis. Intraoperative guidance using Nearinfrared (NIR) fluorescence imaging is a promising technique for tumor...