Xenia L Schafer
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Explore the profile of Xenia L Schafer including associated specialties, affiliations and a list of published articles.
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11
Citations
262
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Recent Articles
1.
Soto C, Lesch M, Becker J, Sharipol A, Khan A, Shafer X, et al.
bioRxiv
. 2024 Aug;
PMID: 39185193
Interactions between acute myeloid leukemia (AML) and the bone marrow microenvironment (BMME) are critical to leukemia progression and chemoresistance. In the solid tumor microenvironment, altered metabolite levels contribute to cancer...
2.
Blick-Nitko S, Ture S, Schafer X, Munger J, Livada A, Li C, et al.
Blood Adv
. 2024 Aug;
8(22):5814-5825.
PMID: 39133890
Platelets are immune responsive in many diseases as noted by changes in platelet messenger RNA in conditions such as sepsis, atherosclerosis, COVID-19, and many other inflammatory and infectious etiologies. The...
3.
Asantewaa G, Tuttle E, Ward N, Kang Y, Kim Y, Kavanagh M, et al.
Nat Commun
. 2024 Jul;
15(1):6152.
PMID: 39034312
Cells rely on antioxidants to survive. The most abundant antioxidant is glutathione (GSH). The synthesis of GSH is non-redundantly controlled by the glutamate-cysteine ligase catalytic subunit (GCLC). GSH imbalance is...
4.
Raymonda M, Rodriguez-Sanchez I, Schafer X, Smorodintsev-Schiller L, Harris I, Munger J
mBio
. 2023 Dec;
15(1):e0303123.
PMID: 38117060
Viruses modulate host cell metabolism to support the mass production of viral progeny. For human cytomegalovirus, we find that the viral U38 protein is critical for driving these pro-viral metabolic...
5.
Raymonda M, Rodriguez-Sanchez I, Schafer X, Smorodintsev-Schiller L, Harris I, Munger J
bioRxiv
. 2023 Jun;
PMID: 37292722
Human cytomegalovirus (HCMV) modulates cellular metabolism to support productive infection, and the HCMV U38 protein drives many aspects of this HCMV-induced metabolic program. However, it remains to be determined whether...
6.
Asantewaa G, Tuttle E, Ward N, Kang Y, Kim Y, Kavanagh M, et al.
bioRxiv
. 2023 Feb;
PMID: 36798186
Cells rely on antioxidants to survive. The most abundant antioxidant is glutathione (GSH). The synthesis of GSH is non-redundantly controlled by the glutamate-cysteine ligase catalytic subunit (GCLC). GSH imbalance is...
7.
Rodriguez-Sanchez I, Schafer X, Monaghan M, Munger J
PLoS Pathog
. 2019 Jan;
15(1):e1007569.
PMID: 30677091
Human Cytomegalovirus (HCMV) infection induces several metabolic activities that are essential for viral replication. Despite the important role that this metabolic modulation plays during infection, the viral mechanisms involved are...
8.
Smith B, Schafer X, Ambeskovic A, Spencer C, Land H, Munger J
Cell Rep
. 2016 Oct;
17(3):821-836.
PMID: 27732857
Metabolic reprogramming is critical to oncogenesis, but the emergence and function of this profound reorganization remain poorly understood. Here we find that cooperating oncogenic mutations drive large-scale metabolic reprogramming, which...
9.
Spencer C, Schafer X, Moorman N, Munger J
J Virol
. 2011 Apr;
85(12):5814-24.
PMID: 21471234
We have previously reported that human cytomegalovirus (HCMV) infection induces large-scale changes to host cell glycolytic, nucleic acid, and phospholipid metabolism. Here we explore the viral mechanisms involved in fatty...
10.
McArdle J, Schafer X, Munger J
J Virol
. 2010 Nov;
85(2):705-14.
PMID: 21084482
Viruses depend on the host cell to provide the energy and biomolecular subunits necessary for production of viral progeny. We have previously reported that human cytomegalovirus (HCMV) infection induces dramatic...