Xavier Didelot
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Explore the profile of Xavier Didelot including associated specialties, affiliations and a list of published articles.
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174
Citations
8884
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Recent Articles
1.
Yang Z, Davies H, Clapham J, Lopez L, Bratcher H, Tiong A, et al.
Infect Genet Evol
. 2025 Feb;
129:105726.
PMID: 39924093
Neisseria meningitidis is the causative agent of invasive meningococcal disease (IMD), a form of bacterial meningitis and septicaemia, leading to isolated cases, outbreaks, and epidemics worldwide. Between 1991 and 2008,...
2.
Helekal D, Koskela J, Didelot X
Syst Biol
. 2025 Jan;
PMID: 39826137
The vast majority of pathogen phylogenetic studies do not consider the possibility of multiple merger events being present, where a single node of the tree leads to more than two...
3.
Wan Y, Myall A, Boonyasiri A, Bolt F, Ledda A, Mookerjee S, et al.
J Infect Dis
. 2024 Jul;
230(1):e159-e170.
PMID: 39052705
Background: Carbapenemase-producing Enterobacterales (CPE) are challenging in healthcare, with resistance to multiple classes of antibiotics. This study describes the emergence of imipenemase (IMP)-encoding CPE among diverse Enterobacterales species between 2016...
4.
Kendall M, Ferretti L, Wymant C, Tsallis D, Petrie J, Di Francia A, et al.
Science
. 2024 Jul;
385(6710):eadm8103.
PMID: 38991048
Understanding the drivers of respiratory pathogen spread is challenging, particularly in a timely manner during an ongoing epidemic. In this work, we present insights that we obtained using daily data...
5.
Vieira A, Wan Y, Ryan Y, Li H, Guy R, Papangeli M, et al.
Nat Commun
. 2024 May;
15(1):3916.
PMID: 38729927
The UK observed a marked increase in scarlet fever and invasive group A streptococcal infection in 2022 with severe outcomes in children and similar trends worldwide. Here we report lineage...
6.
Nair S, Barker C, Bird M, Greig D, Collins C, Painset A, et al.
Microb Genom
. 2024 May;
10(5).
PMID: 38717818
Evidence is accumulating in the literature that the horizontal spread of antimicrobial resistance (AMR) genes mediated by bacteriophages and bacteriophage-like plasmid (phage-plasmid) elements is much more common than previously envisioned....
7.
Moore M, Laager M, Ribeca P, Didelot X
PLoS Genet
. 2024 Apr;
20(4):e1011184.
PMID: 38683871
By decomposing genome sequences into k-mers, it is possible to estimate genome differences without alignment. Techniques such as k-mer minimisers, for example MinHash, have been developed and are often accurate...
8.
Taylor A, Yahara K, Pascoe B, Ko S, Mageiros L, Mourkas E, et al.
mBio
. 2024 Apr;
15(6):e0058124.
PMID: 38683013
Recombination of short DNA fragments via horizontal gene transfer (HGT) can introduce beneficial alleles, create genomic disharmony through negative epistasis, and create adaptive gene combinations through positive epistasis. For non-core...
9.
Avila Cartes J, Bonizzoni P, Ciccolella S, Della Vedova G, Denti L, Didelot X, et al.
Bioinformatics
. 2024 Apr;
40(5).
PMID: 38676570
Motivation: Bacterial genomes present more variability than human genomes, which requires important adjustments in computational tools that are developed for human data. In particular, bacteria exhibit a mosaic structure due...
10.
Osman R, Dema E, David A, Hughes G, Field N, Cole M, et al.
J Infect
. 2024 Apr;
88(6):106168.
PMID: 38670270
Objectives: The utility of whole genome sequencing (WGS) to inform sexually transmitted infection (STI) patient management is unclear. Timely WGS data might support clinical management of STIs by characterising epidemiological...