Wouter H Roos
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Explore the profile of Wouter H Roos including associated specialties, affiliations and a list of published articles.
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92
Citations
1480
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Recent Articles
1.
Hammond J, Richards C, Ko Y, Jonker T, Aberg C, Roos W, et al.
Small
. 2025 Feb;
:e2408039.
PMID: 40007088
Many drug targets are located in intracellular compartments of cells but they often remain inaccessible to standard imaging and therapeutic agents. To aid intracellular delivery, drug carrier nanoparticles have been...
2.
Enterovirus-like particles encapsidate RNA and exhibit decreased stability due to lack of maturation
Kuijpers L, Giannopoulou E, Feng Y, van den Braak W, Freydoonian A, Ramlal R, et al.
PLoS Pathog
. 2025 Feb;
21(2):e1012873.
PMID: 39903789
To counteract hand, foot, and mouth disease-causing viruses such as enterovirus A71 and coxsackievirus A6, virus-like particles (VLPs) have emerged as a leading contender for the development of a multivalent...
3.
Feng Y, van Bodegraven D, Kadek A, L B Munguira I, Soria-Martinez L, Nentwich S, et al.
Nat Commun
. 2024 Nov;
15(1):10076.
PMID: 39572555
High-risk human papillomaviruses (HPVs) cause various cancers. While type-specific prophylactic vaccines are available, additional anti-viral strategies are highly desirable. Initial HPV cell entry involves receptor-switching induced by structural capsid modifications....
4.
Richards C, Melero Martinez P, Roos W, Aberg C
Nanoscale Adv
. 2024 Nov;
7(1):185-195.
PMID: 39569330
Understanding how nanoparticle properties influence uptake by cells is highly important for developing nanomedicine design principles. For this, quantitative studies where actual numbers of cell-associated particles are determined are highly...
5.
de Weerd S, Ruiter E, Calicchia E, Portale G, Schuringa J, Roos W, et al.
Small Methods
. 2024 Oct;
8(12):e2400498.
PMID: 39431332
Cell membrane nanoparticles have attracted increasing interest in nanomedicine because they allow to exploit the complexity of cell membrane interactions for drug delivery. Several methods are used to obtain plasma...
6.
Melcrova A, Klein C, Roos W
Nano Lett
. 2024 Aug;
24(38):11800-11807.
PMID: 39145544
The need to combat antimicrobial resistance is becoming more and more pressing. Here we investigate the working mechanism of a small cationic agent, -alkylamide 3d, by conventional and high-speed atomic...
7.
Piontek M, Roos W
J Extracell Biol
. 2024 Jun;
1(12):e68.
PMID: 38938600
Lipoproteins (LPs) are micelle-like structures with a similar size to extracellular vesicles (EVs) and are therefore often co-isolated, as intensively discussed within the EV community. LPs from human blood plasma...
8.
Palmulli R, Couty M, Piontek M, Ponnaiah M, Dingli F, Verweij F, et al.
Nat Cell Biol
. 2024 Jun;
26(7):1093-1109.
PMID: 38886558
Extracellular vesicles such as exosomes are now recognized as key players in intercellular communication. Their role is influenced by the specific repertoires of proteins and lipids, which are enriched when...
9.
Jekhmane S, Derks M, Maity S, Slingerland C, Tehrani K, Medeiros-Silva J, et al.
Nat Microbiol
. 2024 May;
9(7):1778-1791.
PMID: 38783023
Antimicrobial resistance is a leading cause of mortality, calling for the development of new antibiotics. The fungal antibiotic plectasin is a eukaryotic host defence peptide that blocks bacterial cell wall...
10.
Lira R, Dillingh L, Schuringa J, Yahioglu G, Suhling K, Roos W
Biophys J
. 2024 May;
123(12):1592-1609.
PMID: 38702882
Sensing of the biophysical properties of membranes using molecular reporters has recently regained widespread attention. This was elicited by the development of new probes of exquisite optical properties and increased...