Wolfgang Bielke
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Explore the profile of Wolfgang Bielke including associated specialties, affiliations and a list of published articles.
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9
Citations
119
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Recent Articles
1.
Pitzler L, Auler M, Probst K, Frie C, Bergmeier V, Holzer T, et al.
Stem Cells
. 2016 Mar;
34(5):1297-309.
PMID: 26934179
microRNAs (miRNAs) can regulate the interplay between perivascular cells (PVC) and endothelial cells (EC) during angiogenesis, but the relevant PVC-specific miRNAs are not yet defined. Here, we identified miR-126-3p and...
2.
Bengestrate L, Virtue S, Campbell M, Vidal-Puig A, Hadaschik D, Hahn P, et al.
PLoS One
. 2011 Jul;
6(6):e21305.
PMID: 21731698
In recent years, there has been accumulating evidence that microRNAs are key regulator molecules of gene expression. The cellular processes that are regulated by microRNAs include e.g. cell proliferation, programmed...
3.
4.
Bergauer T, Krueger U, Lader E, Pilk S, Wolter I, Bielke W
Oligonucleotides
. 2009 Feb;
19(1):41-52.
PMID: 19196098
Tremendous efforts have been made to develop short-interfering RNA (siRNA) design algorithms that generate highly functional siRNAs for gene knockdown. Nevertheless, "difficult-to-silence" target messenger RNAs (mRNAs) still exist for which...
5.
Narz F, Hubner S, Magyar S, Bielke W, Weber M, Dennig J
J Biotechnol
. 2007 Jun;
130(3):209-12.
PMID: 17555840
Gene silencing experiments in difficult-to-transfect cells are often hampered by the presence of a background of untransfected cells. We present proof-of-concept data from two different strategies for enrichment of siRNA-transfected...
6.
Hahn P, Niemann G, Grewe A, Bielke W
J Biotechnol
. 2007 Jan;
128(4):762-9.
PMID: 17258833
We describe an siRNA (short interfering RNA)-based approach for temporary and reversible regulation of engineered expression constructs in cells. Control of cloned genes can be achieved by cotransfection of unique...
7.
Hahn P, Schmidt C, Weber M, Kang J, Bielke W
Biomol Eng
. 2004 Nov;
21(3-5):113-7.
PMID: 15567105
mRNA targeted by siRNA is endogeneously cleaved into a 5'- and a 3'-fragment and finally degraded in cells. Little is known about the relative stability and degradation kinetics of these...
8.
Brachvogel B, Reichenberg D, Beyer S, Jehn B, von der Mark K, Bielke W
Gene
. 2002 May;
288(1-2):203-10.
PMID: 12034510
We cloned and characterized the cDNA and the expression pattern of a novel member of the murine 'Disintegrin and Metalloprotease-Domain Family' (ADAM). The predicted protein sequence reveals highest homology to...
9.
Jehn B, Dittert I, Beyer S, von der Mark K, Bielke W
J Biol Chem
. 2002 Jan;
277(10):8033-40.
PMID: 11777909
Regulation of Notch1 activity is critical for cell fate decisions and differentiation of skeletal myoblasts. We have employed the skeletal myoblast cell line C2C12 to study posttranslational regulation of Notch1...