Wojciech Michowski
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Explore the profile of Wojciech Michowski including associated specialties, affiliations and a list of published articles.
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22
Citations
1015
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Recent Articles
1.
Suski J, Ratnayeke N, Braun M, Zhang T, Strmiska V, Michowski W, et al.
Nature
. 2022 May;
605(7909):357-365.
PMID: 35508654
The entry of mammalian cells into the DNA synthesis phase (S phase) represents a key event in cell division. According to current models of the cell cycle, the kinase CDC7...
2.
Fassl A, Brain C, Abu-Remaileh M, Stukan I, Butter D, Stepien P, et al.
Sci Adv
. 2020 Jul;
6(25):eabb2210.
PMID: 32704543
Inhibitors of cyclin-dependent kinases CDK4 and CDK6 have been approved for treatment of hormone receptor-positive breast cancers. In contrast, triple-negative breast cancers (TNBCs) are resistant to CDK4/6 inhibition. Here, we...
3.
Michowski W, Chick J, Chu C, Kolodziejczyk A, Wang Y, Suski J, et al.
Mol Cell
. 2020 Apr;
78(3):459-476.e13.
PMID: 32240602
The cyclin-dependent kinase 1 (Cdk1) drives cell division. To uncover additional functions of Cdk1, we generated knockin mice expressing an analog-sensitive version of Cdk1 in place of wild-type Cdk1. In...
4.
Sharma S, Zhang T, Michowski W, Rebecca V, Xiao M, Ferretti R, et al.
Proc Natl Acad Sci U S A
. 2020 Mar;
117(14):8001-8012.
PMID: 32193336
The cyclin-dependent kinase 5 (CDK5), originally described as a neuronal-specific kinase, is also frequently activated in human cancers. Using conditional CDK5 knockout mice and a mouse model of highly metastatic...
5.
Liu L, Michowski W, Kolodziejczyk A, Sicinski P
Nat Cell Biol
. 2019 Sep;
21(9):1060-1067.
PMID: 31481793
Cyclins, cyclin-dependent kinases and other components of the core cell cycle machinery drive cell division. Growing evidence indicates that this machinery operates in a distinct fashion in some mammalian stem...
6.
Geng Y, Michowski W, Chick J, Wang Y, Jecrois M, Sweeney K, et al.
Proc Natl Acad Sci U S A
. 2018 Jan;
115(5):1015-1020.
PMID: 29339491
E-type cyclins (cyclins E1 and E2) are components of the core cell cycle machinery and are overexpressed in many human tumor types. E cyclins are thought to drive tumor cell...
7.
Zhou J, Tien A, Alberta J, Ficarro S, Griveau A, Sun Y, et al.
Cell Rep
. 2017 Mar;
18(13):3167-3177.
PMID: 28355568
During development of the vertebrate CNS, the basic helix-loop-helix (bHLH) transcription factor Olig2 sustains replication competence of progenitor cells that give rise to neurons and oligodendrocytes. A pathological counterpart of...
8.
Liu L, Michowski W, Inuzuka H, Shimizu K, Nihira N, Chick J, et al.
Nat Cell Biol
. 2017 Feb;
19(3):177-188.
PMID: 28192421
Progression of mammalian cells through the G1 and S phases of the cell cycle is driven by the D-type and E-type cyclins. According to the current models, at least one...
9.
Odajima J, Saini S, Jung P, Ndassa-Colday Y, Ficaro S, Geng Y, et al.
PLoS Genet
. 2016 Nov;
12(11):e1006429.
PMID: 27828963
E-type cyclins (cyclins E1 and E2) are components of the cell cycle machinery that has been conserved from yeast to humans. The major function of E-type cyclins is to drive...
10.
Gygli P, Chang J, Gokozan H, Catacutan F, Schmidt T, Kaya B, et al.
Aging (Albany NY)
. 2016 Jul;
8(7):1540-70.
PMID: 27425845
Various stem cell niches of the brain have differential requirements for Cyclin A2. Cyclin A2 loss results in marked cerebellar dysmorphia, whereas forebrain growth is retarded during early embryonic development...