Wing Hung Wong
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Explore the profile of Wing Hung Wong including associated specialties, affiliations and a list of published articles.
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Articles
105
Citations
4324
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Recent Articles
11.
Li S, Zeng W, Ni X, Liu Q, Li W, Stackpole M, et al.
Proc Natl Acad Sci U S A
. 2023 Jul;
120(28):e2305236120.
PMID: 37399400
Plasma cell-free DNA (cfDNA) is a noninvasive biomarker for cell death of all organs. Deciphering the tissue origin of cfDNA can reveal abnormal cell death because of diseases, which has...
12.
Feng Z, Duren Z, Xin J, Yuan Q, He Y, Su B, et al.
Elife
. 2022 Dec;
11.
PMID: 36525361
Systems genetics holds the promise to decipher complex traits by interpreting their associated SNPs through gene regulatory networks derived from comprehensive multi-omics data of cell types, tissues, and organs. Here,...
13.
Pan X, Ma Z, Sun X, Li H, Zhang T, Zhao C, et al.
Genomics Proteomics Bioinformatics
. 2022 Dec;
21(3):632-648.
PMID: 36494035
The genetic information coded in DNA leads to trait innovation via a gene regulatory network (GRN) in development. Here, we developed a conserved non-coding element interpretation method to integrate multi-omics...
14.
Duren Z, Chang F, Naqing F, Xin J, Liu Q, Wong W
Genome Biol
. 2022 Oct;
23(1):213.
PMID: 36229829
No abstract available.
15.
Zeng W, Liu Q, Yin Q, Jiang R, Wong W
Nucleic Acids Res
. 2022 Oct;
51(D1):D159-D166.
PMID: 36215037
Elucidating the role of 3D architecture of DNA in gene regulation is crucial for understanding cell differentiation, tissue homeostasis and disease development. Among various chromatin conformation capture methods, HiChIP has...
16.
Stackpole M, Zeng W, Li S, Liu C, Zhou Y, He S, et al.
Nat Commun
. 2022 Sep;
13(1):5566.
PMID: 36175411
Early cancer detection by cell-free DNA faces multiple challenges: low fraction of tumor cell-free DNA, molecular heterogeneity of cancer, and sample sizes that are not sufficient to reflect diverse patient...
17.
Xi X, Li H, Chen S, Lv T, Ma T, Jiang R, et al.
iScience
. 2022 Aug;
25(8):104790.
PMID: 35992073
Complex traits such as cardiovascular diseases (CVD) are the results of complicated processes jointly affected by genetic and environmental factors. Genome-wide association studies (GWAS) identified genetic variants associated with diseases...
18.
Lin X, Liu Y, Liu S, Zhu X, Wu L, Zhu Y, et al.
Science
. 2022 Aug;
377(6610):1077-1085.
PMID: 35951677
Mammalian genomes have multiple enhancers spanning an ultralong distance (>megabases) to modulate important genes, but it is unclear how these enhancers coordinate to achieve this task. We combine multiplexed CRISPRi...
19.
Duren Z, Chang F, Naqing F, Xin J, Liu Q, Wong W
Genome Biol
. 2022 May;
23(1):114.
PMID: 35578363
Technological development has enabled the profiling of gene expression and chromatin accessibility from the same cell. We develop scREG, a dimension reduction methodology, based on the concept of cis-regulatory potential,...
20.
Jiang H, Li H, Wong W, Fan X
IEEE/ACM Trans Comput Biol Bioinform
. 2022 May;
20(2):1384-1394.
PMID: 35503836
Deciphering the free energy landscape of biomolecular structure space is crucial for understanding many complex molecular processes, such as protein-protein interaction, RNA folding, and protein folding. A major source of...