Wing-Yu Fu
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Explore the profile of Wing-Yu Fu including associated specialties, affiliations and a list of published articles.
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33
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1295
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Recent Articles
1.
Yang X, Wang Y, Qiao Y, Lin J, Lau J, Fu W, et al.
Proc Natl Acad Sci U S A
. 2025 Feb;
122(7):e2420324122.
PMID: 39928878
Cell surface receptors, including erythropoietin-producing hepatocellular A4 (EphA4), are important in regulating hippocampal synapse loss, which is the key driver of memory decline in Alzheimer's disease (AD). However, the cell-specific...
2.
Fu W, Fu A, Ip N
Neuron
. 2023 Oct;
111(20):3133-3135.
PMID: 37857086
In this issue of Neuron, Essayan-Perez and Südhof demonstrate roles for γ-secretase in the regulation of synaptic functions in human neurons. Chronic attenuation of γ-secretase activity increases synapse formation but...
3.
Jiang Y, Zhou X, Wong H, Ouyang L, Ip F, Chau V, et al.
Nat Aging
. 2023 Apr;
2(7):616-634.
PMID: 37117777
Changes in the levels of circulating proteins are associated with Alzheimer's disease (AD), whereas their pathogenic roles in AD are unclear. Here, we identified soluble ST2 (sST2), a decoy receptor...
4.
Fu W, Ip N
Semin Cell Dev Biol
. 2022 Aug;
139:3-12.
PMID: 35918217
Alzheimer's disease (AD) is a neurodegenerative disease characterized by the progressive deterioration of cognitive functions. Due to the extended global life expectancy, the prevalence of AD is increasing among aging...
5.
Fu W, Hung K, Lau S, Butt B, Yuen V, Fu G, et al.
ACS Chem Neurosci
. 2021 Nov;
12(22):4249-4256.
PMID: 34738783
Alzheimer's disease (AD), the most common neurodegenerative disease, has limited treatment options. As such, extensive studies have been conducted to identify novel therapeutic approaches. We previously reported that rhynchophylline (Rhy),...
6.
Lau J, Tian M, Shen Y, Lau S, Fu W, Fu A, et al.
Sci Rep
. 2021 Feb;
11(1):4359.
PMID: 33623128
Alzheimer's disease (AD) is a devastating neurodegenerative disorder with no disease-modifying treatment. AD progression is characterized by cognitive decline, neuroinflammation, and accumulation of amyloid-beta (Aβ) and neurofibrillary tangles in the...
7.
Wang Y, Fu W, Cheung K, Hung K, Chen C, Geng H, et al.
Proc Natl Acad Sci U S A
. 2021 Jan;
118(1).
PMID: 33443211
Hippocampal synaptic plasticity is important for learning and memory formation. Homeostatic synaptic plasticity is a specific form of synaptic plasticity that is induced upon prolonged changes in neuronal activity to...
8.
Ouyang L, Chen Y, Wang Y, Chen Y, Fu A, Fu W, et al.
Sci Rep
. 2020 Oct;
10(1):18746.
PMID: 33127972
Dendrites, branched structures extending from neuronal cell soma, are specialized for processing information from other neurons. The morphogenesis of dendritic structures is spatiotemporally regulated by well-orchestrated signaling cascades. Dysregulation of...
9.
Lau S, Chen C, Fu W, Qu J, Cheung T, Fu A, et al.
Cell Rep
. 2020 Apr;
31(3):107530.
PMID: 32320664
Impairment of microglial clearance activity contributes to beta-amyloid (Aβ) pathology in Alzheimer's disease (AD). While the transcriptome profile of microglia directs microglial functions, how the microglial transcriptome can be regulated...
10.
Chen W, Fu W, Su Y, Fang W, Fu A, Ip N
Sci Rep
. 2019 Feb;
9(1):1190.
PMID: 30718786
Major depressive disorders are emerging health problems that affect millions of people worldwide. However, treatment options and targets for drug development are limited. Impaired adult hippocampal neurogenesis is emerging as...