Wilma Puzon-McLaughlin
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Explore the profile of Wilma Puzon-McLaughlin including associated specialties, affiliations and a list of published articles.
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10
Citations
607
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Recent Articles
1.
Gingras A, Puzon-McLaughlin W, Bobkov A, Ginsberg M
Structure
. 2016 Nov;
24(12):2152-2162.
PMID: 27839947
Ras-interacting protein 1 (Rasip1) is an endothelial-specific Rap1 and Ras effector, important for vascular development and angiogenesis. Here, we report the crystal structure of the Rasip1 RA domain (RRA) alone,...
2.
Gingras A, Puzon-McLaughlin W, Ginsberg M
J Biol Chem
. 2013 Jul;
288(33):23639-49.
PMID: 23814056
Loss of function mutation in Krev interaction trapped 1 (KRIT1) causes autosomal dominant familial cerebral cavernous malformations and disrupts cardiovascular development. The biological function of KRIT1 requires that its FERM...
3.
Lee H, Lim C, Puzon-McLaughlin W, Shattil S, Ginsberg M
J Biol Chem
. 2008 Dec;
284(8):5119-27.
PMID: 19098287
Rap1 small GTPases interact with Rap1-GTP-interacting adaptor molecule (RIAM), a member of the MRL (Mig-10/RIAM/Lamellipodin) protein family, to promote talin-dependent integrin activation. Here, we show that MRL proteins function as...
4.
Han J, Lim C, Watanabe N, Soriani A, Ratnikov B, Calderwood D, et al.
Curr Biol
. 2006 Sep;
16(18):1796-806.
PMID: 16979556
Background: Integrin receptors, composed of transmembrane alpha and beta subunits, are essential for the development and functioning of multicellular animals. Agonist stimulation leads cells to regulate integrin affinity ("activation"), thus...
5.
Kamata T, Ambo H, Puzon-McLaughlin W, Tieu K, Handa M, Ikeda Y, et al.
Biochem J
. 2003 Dec;
378(Pt 3):1079-82.
PMID: 14690453
Chemical or enzymic reduction/oxidation of integrin cysteine residues (e.g. by reducing agents and protein disulphide isomerase) may be a mechanism for regulating integrin function. It has also been proposed that...
6.
Kariya Y, Tsubota Y, Hirosaki T, Mizushima H, Puzon-McLaughlin W, Takada Y, et al.
J Cell Biochem
. 2003 Jan;
88(3):506-20.
PMID: 12532327
The basement membrane protein laminin-5 promotes cell adhesion and migration. The carboxyl-terminal G3 domain in the alpha3 chain is essential for the unique activity of laminin-5. To investigate the function...
7.
Levesque J, Takada Y, Puzon-McLaughlin W, Simmons P
Hybrid Hybridomics
. 2002 Aug;
21(4):253-60.
PMID: 12193278
Cell adhesion receptors of the integrin superfamily can be expressed in different affinity states towards their ligands. It has been previously demonstrated that beta(1) integrins alpha4beta(1) and alpha5beta(1) are expressed...
8.
Miao H, Li S, Hu Y, Yuan S, Zhao Y, Chen B, et al.
J Cell Sci
. 2002 Apr;
115(Pt 10):2199-206.
PMID: 11973360
Integrins mediate cell adhesion and signal transduction at focal adhesions. Here we investigate the roles of integrin beta subunits in the regulation of actin cytoskeletal structure and the activities of...
9.
Eto K, Huet C, Tarui T, Kupriyanov S, Liu H, Puzon-McLaughlin W, et al.
J Biol Chem
. 2002 Mar;
277(20):17804-10.
PMID: 11882657
ADAMs (a disintegrin and metalloproteases) are members of the metzincin superfamily of metalloproteases. Among integrins binding to disintegrin domains of ADAMs are alpha(9)beta(1) and alpha(v)beta(3), and they bind in an...
10.
Kamata T, Tieu K, Tarui T, Puzon-McLaughlin W, Hogg N, Takada Y
J Immunol
. 2002 Feb;
168(5):2296-301.
PMID: 11859118
The alpha(L) I (inserted or interactive) domain of integrin alpha(L)beta(2) undergoes conformational changes upon activation. Recent studies show that the isolated, activated alpha(L) I domain is sufficient for strong ligand...