William Stecho
Overview
Explore the profile of William Stecho including associated specialties, affiliations and a list of published articles.
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Snapshot
Articles
13
Citations
284
Followers
0
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Recent Articles
1.
Zeng P, Cecchini M, Barrett J, Shammas-Toma M, De Cecco L, Serafini M, et al.
EBioMedicine
. 2022 Nov;
86:104373.
PMID: 36442320
Background: There is significant interest in treatment de-escalation for human papillomavirus-associated (HPV) oropharyngeal squamous cell carcinoma (OPSCC) patients given the generally favourable prognosis. However, 15-30% of patients recur after primary...
2.
Patel K, Cormier N, Fowler J, Partridge A, Theurer J, Black M, et al.
Int J Endocrinol
. 2021 Sep;
2021:8909224.
PMID: 34475951
Objective: Detection of circulating tumor DNA (ctDNA) in cancer patients can potentially serve as a noninvasive, sensitive test of disease status. The purpose of this study was to determine the...
3.
Ruicci K, Meens J, Plantinga P, Stecho W, Pinto N, Yoo J, et al.
J Exp Clin Cancer Res
. 2020 Oct;
39(1):217.
PMID: 33059733
Background: Aberrant activation of the phosphatidylinositol 3-kinase (PI3K) pathway is common in many malignancies, including head and neck squamous cell carcinoma (HNSCC). Despite pre-clinical and clinical studies, outcomes from targeting...
4.
Black M, Ghasemi F, Sun R, Stecho W, Datti A, Meens J, et al.
Oral Oncol
. 2019 Dec;
101:104529.
PMID: 31864959
Objectives: Spleen tyrosine kinase (SYK) is a promoter of cell survival in a variety of cell types, including normal and cancerous epithelial cells. We hypothesized that SYK would an important...
5.
Mundi N, Prokopec S, Ghasemi F, Warner A, Patel K, MacNeil D, et al.
Cancers Head Neck
. 2019 Dec;
4:5.
PMID: 31844556
Background: The genomic landscape of head and neck cancer has been reported through The Cancer Genome Atlas project. We attempt to determine if high-risk human papillomavirus (HPV) or frequently mutated...
6.
Ruicci K, Plantinga P, Pinto N, Khan M, Stecho W, Dhaliwal S, et al.
Mol Oncol
. 2019 Dec;
14(1):230-231.
PMID: 31804024
No abstract available.
7.
Ruicci K, Plantinga P, Pinto N, Khan M, Stecho W, Dhaliwal S, et al.
Mol Oncol
. 2019 Aug;
13(10):2160-2177.
PMID: 31393061
Phosphoinositide 3-kinase (PI3K) is aberrantly activated in head and neck squamous cell carcinomas (HNSCC) and plays a pivotal role in tumorigenesis by driving Akt signaling, leading to cell survival and...
8.
Ghasemi F, Prokopec S, MacNeil D, Mundi N, Gameiro S, Howlett C, et al.
JCI Insight
. 2019 Jan;
4(1).
PMID: 30626742
Smoking has historically been recognized as a negative prognostic factor in head and neck squamous cell carcinoma (HNSCC). This study aimed to assess the mutational differences between heavy smokers (>20...
9.
Papillon-Cavanagh S, Lu C, Gayden T, Mikael L, Bechet D, Karamboulas C, et al.
Nat Genet
. 2017 Jan;
49(2):180-185.
PMID: 28067913
Human papillomavirus (HPV)-negative head and neck squamous cell carcinomas (HNSCCs) are deadly and common cancers. Recent genomic studies implicate multiple genetic pathways, including cell signaling, cell cycle and immune evasion,...
10.
Theurer J, Stecho W, Yoo J, Kwan K, Wehrli B, Harry V, et al.
Pathol Oncol Res
. 2015 Aug;
22(1):35-40.
PMID: 26271341
PIK3CA is the only frequently-mutated, directly druggable oncogene in head and neck squamous cell carcinoma (HNSCC). However, it is unclear if a molecularly-driven intervention trial can be launched successfully, particularly...