Christopher J Howlett
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Explore the profile of Christopher J Howlett including associated specialties, affiliations and a list of published articles.
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28
Citations
601
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Recent Articles
1.
Zeng P, Prokopec S, Lai S, Pinto N, Chan-Seng-Yue M, Clifton-Bligh R, et al.
Cell Rep
. 2024 Feb;
43(3):113826.
PMID: 38412093
Anaplastic thyroid carcinoma is arguably the most lethal human malignancy. It often co-occurs with differentiated thyroid cancers, yet the molecular origins of its aggressivity are unknown. We sequenced tumor DNA...
2.
Shin A, Tesfagiorgis Y, Larsen F, Derouet M, Zeng P, Good H, et al.
Gastroenterology
. 2023 Jan;
164(4):593-609.e13.
PMID: 36634827
Background & Aims: Colorectal cancer is a leading cause of cancer death, and a major risk factor is chronic inflammation. Despite the link between colitis and cancer, the mechanism by...
3.
Zeng P, Cecchini M, Barrett J, Shammas-Toma M, De Cecco L, Serafini M, et al.
EBioMedicine
. 2022 Nov;
86:104373.
PMID: 36442320
Background: There is significant interest in treatment de-escalation for human papillomavirus-associated (HPV) oropharyngeal squamous cell carcinoma (OPSCC) patients given the generally favourable prognosis. However, 15-30% of patients recur after primary...
4.
Kum J, Howlett C, Khan Z
Commun Biol
. 2022 Oct;
5(1):1145.
PMID: 36307522
Diabetes affects select organs such as the eyes, kidney, heart, and brain. Our recent studies show that diabetes also enhances adipogenesis in the bone marrow and reduces the number of...
5.
Grafodatskaya D, ORielly D, Bedard K, Butcher D, Howlett C, Lytwyn A, et al.
J Med Genet
. 2022 Apr;
59(8):727-736.
PMID: 35393334
The purpose of this document is to provide pre-analytical, analytical and post-analytical considerations and recommendations to Canadian clinical laboratories developing, validating and offering next-generation sequencing (NGS)-based and () tumour testing...
6.
Park P, Kurek K, DeCoteau J, Howlett C, Hawkins C, Izevbaye I, et al.
Am J Clin Pathol
. 2022 Feb;
158(1):105-111.
PMID: 35195689
Objectives: In precision medicine, where oncologic management is tailored to the individual's clinical and genetic profiles, advanced diagnostic testing provides prognostic information and guides management in a growing number of...
7.
Ziai H, Warner A, Mundi N, Patel K, Chung E, Howlett C, et al.
Int J Otolaryngol
. 2021 Apr;
2021:6672373.
PMID: 33824664
Background: Recently, reanalysis of The Cancer Genome Atlas study demonstrated that human papillomavirus (HPV) genotypes in head and neck cancers other than HPV-16 have inferior survival to HPV-16-positive tumors. We...
8.
Gameiro S, Ghasemi F, Zeng P, Mundi N, Howlett C, Plantinga P, et al.
Infect Agent Cancer
. 2021 Feb;
16(1):13.
PMID: 33588906
Background: Frequent mutations in the nuclear receptor binding SET domain protein 1 (NSD1) gene have been observed in head and neck squamous cell carcinomas (HNSCC). NSD1 encodes a histone 3...
9.
Ruicci K, Meens J, Plantinga P, Stecho W, Pinto N, Yoo J, et al.
J Exp Clin Cancer Res
. 2020 Oct;
39(1):217.
PMID: 33059733
Background: Aberrant activation of the phosphatidylinositol 3-kinase (PI3K) pathway is common in many malignancies, including head and neck squamous cell carcinoma (HNSCC). Despite pre-clinical and clinical studies, outcomes from targeting...
10.
Black M, Ghasemi F, Sun R, Stecho W, Datti A, Meens J, et al.
Oral Oncol
. 2019 Dec;
101:104529.
PMID: 31864959
Objectives: Spleen tyrosine kinase (SYK) is a promoter of cell survival in a variety of cell types, including normal and cancerous epithelial cells. We hypothesized that SYK would an important...