William R Scott
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Explore the profile of William R Scott including associated specialties, affiliations and a list of published articles.
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36
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5906
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Recent Articles
1.
Davies I, Adriaenssens A, Scott W, Carling D, Murphy K, Minnion J, et al.
Mol Metab
. 2025 Jan;
92:102094.
PMID: 39788289
Objectives: There is renewed interest in targeting the glucose-dependent insulinotropic polypeptide receptor (GIPR) for treatment of obesity and type 2 diabetes. G-protein coupled receptor desensitisation is suggested to reduce the...
2.
Pirri D, Tian S, Tardajos-Ayllon B, Irving S, Donati F, Allen S, et al.
Circ Res
. 2024 Sep;
135(8):822-837.
PMID: 39234692
Background: Atherosclerotic plaques form unevenly due to disturbed blood flow, causing localized endothelial cell (EC) dysfunction. Obesity exacerbates this process, but the underlying molecular mechanisms are unclear. The transcription factor...
3.
Pastika L, Sau A, Patlatzoglou K, Sieliwonczyk E, Ribeiro A, McGurk K, et al.
NPJ Digit Med
. 2024 Jun;
7(1):167.
PMID: 38918595
The electrocardiogram (ECG) can capture obesity-related cardiac changes. Artificial intelligence-enhanced ECG (AI-ECG) can identify subclinical disease. We trained an AI-ECG model to predict body mass index (BMI) from the ECG...
4.
McAllan L, Baranasic D, Villicana S, Brown S, Zhang W, Lehne B, et al.
Nat Commun
. 2023 May;
14(1):2784.
PMID: 37188674
DNA methylation variations are prevalent in human obesity but evidence of a causative role in disease pathogenesis is limited. Here, we combine epigenome-wide association and integrative genomics to investigate the...
5.
Hawe J, Wilson R, Schmid K, Zhou L, Lakshmanan L, Lehne B, et al.
Nat Genet
. 2022 Jan;
54(1):18-29.
PMID: 34980917
We determined the relationships between DNA sequence variation and DNA methylation using blood samples from 3,799 Europeans and 3,195 South Asians. We identify 11,165,559 SNP-CpG associations (methylation quantitative trait loci...
6.
Clark D, Okada Y, Moore K, Mason D, Pirastu N, Gandin I, et al.
Nat Commun
. 2019 Nov;
10(1):4957.
PMID: 31673082
In many species, the offspring of related parents suffer reduced reproductive success, a phenomenon known as inbreeding depression. In humans, the importance of this effect has remained unclear, partly because...
7.
Sung Y, de las Fuentes L, Winkler T, Chasman D, Bentley A, Kraja A, et al.
Hum Mol Genet
. 2019 May;
28(15):2615-2633.
PMID: 31127295
Elevated blood pressure (BP), a leading cause of global morbidity and mortality, is influenced by both genetic and lifestyle factors. Cigarette smoking is one such lifestyle factor. Across five ancestries,...
8.
Bentley A, Sung Y, Brown M, Winkler T, Kraja A, Ntalla I, et al.
Nat Genet
. 2019 Mar;
51(4):636-648.
PMID: 30926973
The concentrations of high- and low-density-lipoprotein cholesterol and triglycerides are influenced by smoking, but it is unknown whether genetic associations with lipids may be modified by smoking. We conducted a...
9.
de Vries P, Brown M, Bentley A, Sung Y, Winkler T, Ntalla I, et al.
Am J Epidemiol
. 2019 Jan;
188(6):1033-1054.
PMID: 30698716
A person's lipid profile is influenced by genetic variants and alcohol consumption, but the contribution of interactions between these exposures has not been studied. We therefore incorporated gene-alcohol interactions into...
10.
Ligthart S, Vaez A, Vosa U, Stathopoulou M, de Vries P, Prins B, et al.
Am J Hum Genet
. 2018 Nov;
103(5):691-706.
PMID: 30388399
C-reactive protein (CRP) is a sensitive biomarker of chronic low-grade inflammation and is associated with multiple complex diseases. The genetic determinants of chronic inflammation remain largely unknown, and the causal...