Philippe Froguel
Overview
Explore the profile of Philippe Froguel including associated specialties, affiliations and a list of published articles.
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504
Citations
43661
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Recent Articles
1.
Wallis N, McClellan A, Morseburg A, Kentistou K, Jamaluddin A, Dowsett G, et al.
Science
. 2025 Mar;
:eads2145.
PMID: 40048553
Obesity is a heritable disease, but its genetic basis is incompletely understood. Canine population history facilitates trait mapping. We performed a canine genome-wide association study for body condition score, a...
2.
Le Collen L, Desgrouas C, Lukas Croisier C, Creugnet B, Dechaume A, Toussaint B, et al.
Eur J Endocrinol
. 2025 Feb;
192(3):240-247.
PMID: 39993161
Objective: The global increase in the prevalence of metabolic syndrome represents a significant public health concern. Rare biallelic pathogenic variants in ZMPSTE24 have been identified as the cause of mandibuloacral...
3.
Bonnefond A, Florez J, Loos R, Froguel P
Lancet Diabetes Endocrinol
. 2025 Jan;
13(2):149-164.
PMID: 39818223
Diabetes is a leading cause of global mortality and disability, and its economic burden is substantial. This Review focuses on type 2 diabetes, which makes up 90-95% of all diabetes...
4.
Deslande M, Puig-Castellvi F, Castro-Dionicio I, Pacheco-Tapia R, Raverdy V, Caiazzo R, et al.
Mol Metab
. 2025 Jan;
92:102090.
PMID: 39746606
Objective: Metabolic dysfunction-associated steatotic liver disease (MASLD) is characterised by lipid accumulation in the liver and is often associated with obesity and type 2 diabetes. The gut microbiome recently emerged...
5.
Burrows K, Heiskala A, Bradfield J, Balkhiyarova Z, Ning L, Boissel M, et al.
Nat Commun
. 2024 Nov;
15(1):10067.
PMID: 39567492
Genetic effects on changes in human traits over time are understudied and may have important pathophysiological impact. We propose a framework that enables data quality control, implements mixed models to...
6.
Delplanque J, Le Collen L, Loiselle H, Leloire A, Toussaint B, Vaillant E, et al.
Am J Hum Genet
. 2024 Nov;
111(12):2668-2674.
PMID: 39561769
Individuals with obesity caused by biallelic pathogenic LEPR (leptin receptor) variants can benefit from setmelanotide, the novel MC4R agonist. An ongoing phase 3 clinical trial (NCT05093634) includes individuals with obesity...
7.
8.
Saeed S, Bonnefond A, Froguel P
Mol Psychiatry
. 2024 Sep;
30(2):651-658.
PMID: 39237720
Obesity represents an escalating global health burden with profound medical and economic impacts. The conventional perspective on obesity revolves around its classification as a "pure" metabolic disorder, marked by an...
9.
Maurin L, Marselli L, Boissel M, Ning L, Boutry R, Fernandes J, et al.
Diabetes
. 2024 Aug;
73(11):1908-1918.
PMID: 39137110
Article Highlights:
10.
Meulebrouck S, Merrheim J, Queniat G, Bourouh C, Derhourhi M, Boissel M, et al.
Nat Commun
. 2024 Aug;
15(1):6627.
PMID: 39103322
Functional genetics has identified drug targets for metabolic disorders. Opioid use impacts metabolic homeostasis, although mechanisms remain elusive. Here, we explore the OPRD1 gene (encoding delta opioid receptor, DOP) to...