William R P Denault
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Explore the profile of William R P Denault including associated specialties, affiliations and a list of published articles.
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12
Citations
92
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Recent Articles
1.
Haftorn K, Romanowska J, Lee Y, Page C, Magnus P, Haberg S, et al.
Clin Epigenetics
. 2023 Jul;
15(1):114.
PMID: 37443060
Background: DNA methylation (DNAm) is robustly associated with chronological age in children and adults, and gestational age (GA) in newborns. This property has enabled the development of several epigenetic clocks...
2.
Romanowska J, Nustad H, Page C, Denault W, Lee Y, Magnus M, et al.
Hum Genomics
. 2023 Apr;
17(1):35.
PMID: 37085889
Background: Assisted reproductive technologies (ART) may perturb DNA methylation (DNAm) in early embryonic development. Although a handful of epigenome-wide association studies of ART have been published, none have investigated CpGs...
3.
Haftorn K, Denault W, Lee Y, Page C, Romanowska J, Lyle R, et al.
Commun Biol
. 2023 Feb;
6(1):224.
PMID: 36849614
Determining if specific cell type(s) are responsible for an association between DNA methylation (DNAm) and a given phenotype is important for understanding the biological mechanisms underlying the association. Our EWAS...
4.
Denault W, Bohlin J, Page C, Burgess S, Jugessur A
PLoS Comput Biol
. 2022 Aug;
18(8):e1010268.
PMID: 36037248
Bias from weak instruments may undermine the ability to estimate causal effects in instrumental variable regression (IVR). We present here a new approach to handling weak instrument bias through the...
5.
Haberg S, Page C, Lee Y, Nustad H, Magnus M, Haftorn K, et al.
Nat Commun
. 2022 Apr;
13(1):1896.
PMID: 35393427
Assisted reproductive technology (ART) may affect fetal development through epigenetic mechanisms as the timing of ART procedures coincides with the extensive epigenetic remodeling occurring between fertilization and embryo implantation. However,...
6.
Denault W, Gjessing H, Juodakis J, Jacobsson B, Jugessur A
BMC Bioinformatics
. 2021 Oct;
22(1):484.
PMID: 34620077
Background: Traditional methods for single-variant genome-wide association study (GWAS) incur a substantial multiple-testing burden because of the need to test for associations with a vast number of single-nucleotide polymorphisms (SNPs)...
7.
Denault W, Jugessur A
BMC Bioinformatics
. 2021 May;
22(1):276.
PMID: 34039267
No abstract available.
8.
Denault W, Romanowska J, Haaland O, Lyle R, Taylor J, Xu Z, et al.
NAR Genom Bioinform
. 2021 May;
3(2):lqab035.
PMID: 33987535
DNA methylation is the most widely studied epigenetic mark in humans and plays an essential role in normal biological processes as well as in disease development. More focus has recently...
9.
Denault W, Romanowska J, Helgeland O, Jacobsson B, Gjessing H, Jugessur A
BMC Genomics
. 2021 May;
22(1):321.
PMID: 33932983
Background: Birth weight (BW) is one of the most widely studied anthropometric traits in humans because of its role in various adult-onset diseases. The number of loci associated with BW...
10.
Haftorn K, Lee Y, Denault W, Page C, Nustad H, Lyle R, et al.
Clin Epigenetics
. 2021 Apr;
13(1):82.
PMID: 33875015
Background: Gestational age is a useful proxy for assessing developmental maturity, but correct estimation of gestational age is difficult using clinical measures. DNA methylation at birth has proven to be...