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William Pilcher

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Articles 10
Citations 41
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Recent Articles
1.
Sendilraj V, Pilcher W, Choi D, Bhasin A, Bhadada A, Bhadadaa S, et al.
Front Endocrinol (Lausanne) . 2024 Oct; 15:1386613. PMID: 39381435
Introduction: Diabetic foot ulcers (DFUs) are a severe complication among diabetic patients, often leading to amputation or even death. Early detection of infection and ischemia is essential for improving healing...
2.
Choi D, Bakhtiari M, Pilcher W, Huang C, Thomas B, Mumme H, et al.
J Invest Dermatol . 2024 Aug; 145(3):678-690. PMID: 39127092
Diabetic foot ulcer is a critical complication of diabetes, but the wound microenvironment and its healing process are not completely understood. In this study, we optimized single-cell profiling from sharp...
3.
Michaud M, Mota L, Bakhtiari M, Thomas B, Tomeo J, Pilcher W, et al.
Circ Res . 2024 May; 135(1):110-134. PMID: 38808504
Background: Vein graft failure following cardiovascular bypass surgery results in significant patient morbidity and cost to the healthcare system. Vein graft injury can occur during autogenous vein harvest and preparation,...
4.
Michaud M, Mota L, Bakhtiari M, Thomas B, Tomeo J, Pilcher W, et al.
bioRxiv . 2023 Nov; PMID: 37961724
Background: Vein graft failure (VGF) following cardiovascular bypass surgery results in significant patient morbidity and cost to the healthcare system. Vein graft injury can occur during autogenous vein harvest and...
5.
Bhasin S, Thomas B, Summers R, Sarkar D, Mumme H, Pilcher W, et al.
Sci Rep . 2023 Aug; 13(1):12556. PMID: 37532715
Different driver mutations and/or chromosomal aberrations and dysregulated signaling interactions between leukemia cells and the immune microenvironment have been implicated in the development of T-cell acute lymphoblastic leukemia (T-ALL). To...
6.
Geitgey D, Lee M, Cottrill K, Jaffe M, Pilcher W, Bhasin S, et al.
J Natl Cancer Inst Monogr . 2023 May; 2023(61):12-29. PMID: 37139973
The obesity pandemic currently affects more than 70 million Americans and more than 650 million individuals worldwide. In addition to increasing susceptibility to pathogenic infections (eg, SARS-CoV-2), obesity promotes the...
7.
Yao L, Jayasinghe R, Lee B, Bhasin S, Pilcher W, Doxie D, et al.
Cancer Res Commun . 2023 Mar; 2(10):1255-1265. PMID: 36969740
Significance: scRNA-seq, CyTOF, and CITE-seq are increasingly used for evaluating cellular heterogeneity. Understanding their concordances is of great interest. To date, this study is the most comprehensive examination of the...
8.
Pilcher W, Thomas B, Bhasin S, Jayasinghe R, Yao L, Gonzalez-Kozlova E, et al.
NPJ Genom Med . 2023 Jan; 8(1):3. PMID: 36702834
Despite advancements in understanding the pathophysiology of Multiple Myeloma (MM), the cause of rapid progressing disease in a subset of patients is still unclear. MM's progression is facilitated by complex...
9.
Pilcher W, Yang X, Zhurikhina A, Chernaya O, Xu Y, Qiu P, et al.
PLoS Comput Biol . 2020 Sep; 16(9):e1007758. PMID: 32881897
With the ever-increasing quality and quantity of imaging data in biomedical research comes the demand for computational methodologies that enable efficient and reliable automated extraction of the quantitative information contained...
10.
Chernaya O, Zhurikhina A, Hladyshau S, Pilcher W, Young K, Ortner J, et al.
iScience . 2018 Nov; 9:347-358. PMID: 30453164
At early stages of organismal development, endothelial cells self-organize into complex networks subsequently giving rise to mature blood vessels. The compromised collective behavior of endothelial cells leads to the development...