William M Oldham
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Explore the profile of William M Oldham including associated specialties, affiliations and a list of published articles.
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70
Citations
2360
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Recent Articles
1.
Kheyfets V, Sweatt A, Zhang H, Nemkov T, Heerdt P, Dzieciatkowska M, et al.
medRxiv
. 2025 Jan;
PMID: 39763543
Background: Pulmonary arterial hypertension (PAH) is a rare but severe and life-threatening condition that primarily affects the pulmonary blood vessels and the right ventricle of the heart. The limited availability...
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Nguyen H, Jeong Y, Kim Y, Kamiya M, Kim Y, Athar H, et al.
Proc Natl Acad Sci U S A
. 2024 Dec;
121(50):e2401899121.
PMID: 39636853
Fibrosis drives end-organ damage in many diseases. However, clinical trials targeting individual upstream activators of fibroblasts, such as TGFβ, have largely failed. Here, we target the leukemia inhibitory factor receptor...
4.
Tamura T, Cheng C, Villasenor-Altamirano A, Yamada K, Ikeda K, Hayashida K, et al.
Sci Transl Med
. 2024 Dec;
16(776):eadq5796.
PMID: 39630883
Neurological injury drives most deaths and morbidity among patients hospitalized for out-of-hospital cardiac arrest (OHCA). Despite its clinical importance, there are no effective pharmacological therapies targeting post-cardiac arrest (CA) neurological...
5.
Torrino S, Oldham W, R Tejedor A, Burgos I, Nasr L, Rachedi N, et al.
Cell
. 2024 Nov;
188(2):447-464.e20.
PMID: 39591966
Condensed droplets of protein regulate many cellular functions, yet the physiological conditions regulating their formation remain largely unexplored. Increasing our understanding of these mechanisms is paramount, as failure to control...
6.
Xiao W, Shrimali N, Vigder N, Oldham W, Clish C, He H, et al.
Nat Metab
. 2024 Nov;
6(11):2203.
PMID: 39501107
No abstract available.
7.
Xiao W, Shrimali N, Vigder N, Oldham W, Clish C, He H, et al.
Nat Metab
. 2024 Oct;
6(11):2138-2156.
PMID: 39472756
Hypoxia-inducible factor 1α (HIF1α) is a master regulator of biological processes in hypoxia. Yet, the mechanisms and biological consequences of aerobic HIF1α activation by intrinsic factors, particularly in normal (primary)...
8.
McGarrity S, Ziehr D, Austin-Tse C, Wein M, Chivukula R, Oldham W
Circ Genom Precis Med
. 2024 Sep;
17(5):e004741.
PMID: 39328057
No abstract available.
9.
Chakraborty A, Bandyopadhaya A, Singh V, Kovacic F, Cha S, Oldham W, et al.
Elife
. 2024 Sep;
13.
PMID: 39269443
How bacterial pathogens exploit host metabolism to promote immune tolerance and persist in infected hosts remains elusive. To achieve this, we show that () a recalcitrant pathogen, utilizes the quorum...
10.
Kamiya M, Carter H, Espindola M, Doyle T, Lee J, Merriam L, et al.
Cell
. 2024 Jul;
187(14):3506-3530.
PMID: 38996486
Fibrotic interstitial lung diseases (fILDs) have poor survival rates and lack effective therapies. Despite evidence for immune mechanisms in lung fibrosis, immunotherapies have been unsuccessful for major types of fILD....