William L Pak
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Explore the profile of William L Pak including associated specialties, affiliations and a list of published articles.
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18
Citations
316
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Recent Articles
1.
Minke B, Pak W
J Neurogenet
. 2022 Oct;
36(2-3):55-64.
PMID: 36217603
The light-activated Transient Receptor Potential (TRP) channel is the founding member of a large and diverse family of channel proteins. The TRP (dTRP) channel, which generates the electrical response to...
2.
Pak W, Shino S, Leung H
J Neurogenet
. 2012 Jan;
26(2):216-37.
PMID: 22283778
Our objective is to present a comprehensive view of the PDA (prolonged depolarizing afterpotential)-defective Drosophila mutants, nina's and ina's, from the discussion of the PDA and the PDA-based mutant screening...
3.
Long A, Mahapatra C, Woodruff 3rd E, Rohrbough J, Leung H, Shino S, et al.
J Cell Sci
. 2010 Sep;
123(Pt 19):3303-15.
PMID: 20826458
A systematic Drosophila forward genetic screen for photoreceptor synaptic transmission mutants identified no-on-and-no-off transient C (nonC) based on loss of retinal synaptic responses to light stimulation. The cloned gene encodes...
4.
Pak W
J Neurogenet
. 2010 Jun;
24(2):55-66.
PMID: 20536286
This review recounts the early history of Drosophila phototransduction genetics, covering the period between approximately 1966 to 1979. Early in this period, the author felt that there was an urgent...
5.
Watson G, Chouinard S, Cook K, Geng C, Gifford J, Gustafson G, et al.
Insect Biochem Mol Biol
. 2009 Dec;
40(5):376-84.
PMID: 19944756
Strains of Drosophila melanogaster with resistance to the insecticides spinosyn A, spinosad, and spinetoram were produced by chemical mutagenesis. These spinosyn-resistant strains were not cross-resistant to other insecticides. The two...
6.
Shahrestani P, Leung H, Le P, Pak W, Tse S, Ocorr K, et al.
PLoS One
. 2009 Sep;
4(8):e6867.
PMID: 19718456
Optic Atrophy 1 (OPA1) is a ubiquitously expressed dynamin-like GTPase in the inner mitochondrial membrane. It plays important roles in mitochondrial fusion, apoptosis, reactive oxygen species (ROS) and ATP production....
7.
Lu H, Leung H, Wang N, Pak W, Shieh B
J Biol Chem
. 2009 Mar;
284(17):11100-9.
PMID: 19254957
Ca(2+) modulates the visual response in both vertebrates and invertebrates. In Drosophila photoreceptors, an increase of cytoplasmic Ca(2+) mimics light adaptation. Little is known regarding the mechanism, however. We explored...
8.
Leung H, Tseng-Crank J, Kim E, Mahapatra C, Shino S, Zhou Y, et al.
Neuron
. 2008 Jun;
58(6):884-96.
PMID: 18579079
In Drosophila, a phospholipase C-mediated signaling cascade links photoexcitation of rhodopsin to the opening of the TRP/TRPL channels. A lipid product of the cascade, diacylglycerol (DAG) and its metabolite(s), polyunsaturated...
9.
Long A, Kim E, Leung H, Woodruff 3rd E, An L, Doerge R, et al.
J Neurosci
. 2008 Apr;
28(14):3668-82.
PMID: 18385325
A systematic forward genetic Drosophila screen for electroretinogram mutants lacking synaptic transients identified the fuseless (fusl) gene, which encodes a predicted eight-pass transmembrane protein in the presynaptic membrane. Null fusl...
10.
Wang N, Leung H, Pak W, Carl Y, Wadzinski B, Shieh B
J Neurosci
. 2008 Feb;
28(6):1444-51.
PMID: 18256265
Drosophila visual signaling, a G-protein-coupled phospholipase Cbeta (PLCbeta)-mediated mechanism, is regulated by eye-protein kinase C (PKC) that promotes light adaptation and fast deactivation, most likely via phosphorylation of inactivation no...