William K Gottschalk
Overview
Explore the profile of William K Gottschalk including associated specialties, affiliations and a list of published articles.
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Articles
9
Citations
175
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0
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Recent Articles
1.
Gottschalk W, Mahon S, Hodgson D, Barrera J, Hill D, Wei A, et al.
J Alzheimers Dis
. 2023 Jul;
94(4):1563-1576.
PMID: 37458041
Background: The human chromosome 19q13.32 is a gene rich region and has been associated with multiple phenotypes, including late onset Alzheimer's disease (LOAD) and other age-related conditions. Objective: Here we...
2.
Li T, Pappas C, Le S, Wang Q, Klinedinst B, Larsen B, et al.
Neurobiol Aging
. 2021 Nov;
109:158-165.
PMID: 34740077
The Apolipoprotein E ε4 (APOE ε4) haplotype is the strongest genetic risk factor for late-onset Alzheimer's disease (AD). The Translocase of Outer Mitochondrial Membrane-40 (TOMM40) gene maintains cellular bioenergetics, which...
3.
Chiba-Falek O, Gottschalk W, Lutz M
Alzheimers Dement
. 2018 Mar;
14(5):692-698.
PMID: 29524426
The TOMM40 poly-T is a polymorphism in intron 6 of the TOMM40 gene, which is adjacent to and in linkage disequilibrium with APOE. Roses et al. identified the association between...
4.
Subramanian S, Gottschalk W, Kim S, Roses A, Chiba-Falek O
Biochim Biophys Acta Mol Basis Dis
. 2017 Jan;
1863(3):810-816.
PMID: 28065845
Chromosome 19q13.32 is a gene rich region, and has been implicated in multiple human phenotypes in adulthood including lipids traits, Alzheimer's disease, and longevity. Peroxisome Proliferator Activated Receptor Gamma (PPARγ)...
5.
Gottschalk W, Mihovilovic M, Roses A, Chiba-Falek O
J Alzheimers Dis Parkinsonism
. 2016 Apr;
6(1).
PMID: 27104063
No abstract available.
6.
Gottschalk W, Lutz M, Ting He Y, Saunders A, Burns D, Roses A, et al.
J Parkinsons Dis Alzheimers Dis
. 2015 Mar;
1(1).
PMID: 25745640
Mitochondrial dysfunction is an important factor in the pathogenesis of age-related diseases, including neurodegenerative diseases like Alzheimer's and Parkinson's spectrum disorders. A polymorphism in Translocase of the Outer Mitochondrial Membrane...
7.
Effects of low doses of pioglitazone on resting-state functional connectivity in conscious rat brain
Crenshaw D, Asin K, Gottschalk W, Liang Z, Zhang N, Roses A
PLoS One
. 2015 Feb;
10(2):e0117973.
PMID: 25671601
Pioglitazone (PIO) is a peroxisome proliferator-activated receptor-γ (PPARγ) agonist in clinical use for treatment of type 2 diabetes (T2DM). Accumulating evidence suggests PPARγ agonists may be useful for treating or...
8.
Madauss K, Burkhart W, Consler T, Cowan D, Gottschalk W, Miller A, et al.
Acta Crystallogr D Biol Crystallogr
. 2009 Apr;
65(Pt 5):449-61.
PMID: 19390150
Inhibition of acetyl-CoA carboxylase (ACC) may prevent lipid-induced insulin resistance and type 2 diabetes, making the enzyme an attractive pharmaceutical target. Although the enzyme is highly conserved amongst animals, only...
9.
Lenhard J, Gottschalk W
Adv Drug Deliv Rev
. 2002 Oct;
54(9):1199-212.
PMID: 12393301
Type 2 diabetes is associated with insulin resistance in peripheral tissues, such as muscle and fat, impaired glucose-stimulated insulin secretion from pancreatic beta-cells and elevated hepatic gluconeogenesis. Current pharmacotherapy does...