William Jou
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Explore the profile of William Jou including associated specialties, affiliations and a list of published articles.
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25
Citations
1574
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Recent Articles
1.
Lute B, Jou W, Lateef D, Goldgof M, Xiao C, Pinol R, et al.
Cell Metab
. 2014 Jul;
20(2):333-45.
PMID: 24981835
The melanocortin system regulates metabolic homeostasis and inflammation. Melanocortin agonists have contradictorily been reported to both increase and decrease metabolic rate and body temperature. We find two distinct physiologic responses...
2.
Goldgof M, Xiao C, Chanturiya T, Jou W, Gavrilova O, Reitman M
J Biol Chem
. 2014 May;
289(28):19341-50.
PMID: 24872412
The chemical uncoupler 2,4-dinitrophenol (DNP) was an effective and widely used weight loss drug in the early 1930s. However, the physiology of DNP has not been studied in detail because...
3.
Li J, Jain S, McMillin S, Cui Y, Gautam D, Sakamoto W, et al.
Endocrinology
. 2013 Jul;
154(10):3539-51.
PMID: 23861369
Increased hepatic glucose production is a key pathophysiological feature of type 2 diabetes. Like all other cell types, hepatocytes express many G protein-coupled receptors (GPCRs) that are linked to different...
4.
Ruiz de Azua I, Nakajima K, Rossi M, Cui Y, Jou W, Gavrilova O, et al.
FASEB J
. 2012 Jun;
26(10):4275-86.
PMID: 22730439
Spinophilin (SPL), a multidomain scaffolding protein known to modulate the activity of different G-protein-coupled receptors, regulates various central nervous system (CNS) functions. However, little is known about the role of...
5.
Guo T, Bond N, Jou W, Gavrilova O, Portas J, McPherron A
Diabetes
. 2012 May;
61(10):2414-23.
PMID: 22596054
Lipodystrophies are characterized by a loss of white adipose tissue, which causes ectopic lipid deposition, peripheral insulin resistance, reduced adipokine levels, and increased food intake (hyperphagia). The growth factor myostatin...
6.
Jiang C, Qu A, Matsubara T, Chanturiya T, Jou W, Gavrilova O, et al.
Diabetes
. 2011 Aug;
60(10):2484-95.
PMID: 21873554
Objective: Obesity, insulin resistance, and type 2 diabetes form a tightly correlated cluster of metabolic disorders in which adipose is one of the first affected tissues. The role of hypoxia...
7.
Faulhaber-Walter R, Jou W, Mizel D, Li L, Zhang J, Kim S, et al.
Diabetes
. 2011 Aug;
60(10):2578-87.
PMID: 21831968
Objective: The role of adenosine (ADO) in the regulation of glucose homeostasis is not clear. In the current study, we used A1-ADO receptor (A1AR)-deficient mice to investigate the role of...
8.
Chatterjee R, Bhattacharya P, Gavrilova O, Glass K, Moitra J, Myakishev M, et al.
J Mol Endocrinol
. 2011 Feb;
46(3):175-92.
PMID: 21321096
Adipose-specific inactivation of both AP-1 and CCAAT-enhancer-binding protein (C/EBP) families of B-ZIP transcription factors in transgenic mice causes severe lipoatrophy. To evaluate whether inactivation of only C/EBP members was critical...
9.
Xiao C, Kim H, Lahusen T, Wang R, Xu X, Gavrilova O, et al.
J Biol Chem
. 2010 Sep;
285(47):36776-84.
PMID: 20847051
Glucose homeostasis in mammals is mainly regulated by insulin signaling. It was previously shown that SIRT6 mutant mice die before 4 weeks of age, displaying profound abnormalities, including low insulin,...
10.
Gautam D, Ruiz de Azua I, Li J, Guettier J, Heard T, Cui Y, et al.
Endocrinology
. 2010 Sep;
151(11):5185-94.
PMID: 20843999
Previous studies have shown that β-cell M(3) muscarinic acetylcholine receptors (M3Rs) play a key role in maintaining blood glucose homeostasis by enhancing glucose-dependent insulin release. In this study, we tested...