William J Netzer
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Explore the profile of William J Netzer including associated specialties, affiliations and a list of published articles.
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17
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1018
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Recent Articles
1.
Netzer W, Sinha A, Ghias M, Chang E, Gindinova K, Mui E, et al.
Front Chem
. 2024 Oct;
12:1381205.
PMID: 39439934
We previously showed that the anticancer drug imatinib mesylate (IMT, trade name: Gleevec) and a chemically distinct compound, DV2-103 (a kinase-inactive derivative of the potent Abl and Src kinase inhibitor,...
2.
Sinha A, Gindinova K, Mui E, Netzer W, Sinha S
ACS Med Chem Lett
. 2019 Oct;
10(10):1430-1435.
PMID: 31620229
Compound , DV2-103, is a kinase inactive analogue of a potent Abl1/Src kinase inhibitor, PD173955, . Both compounds, and , are known to reduce production of beta amyloid (Aβ) peptide...
3.
Sun W, Netzer W, Sinha A, Gindinova K, Chang E, Sinha S
J Med Chem
. 2019 Mar;
62(6):3122-3134.
PMID: 30873837
Imatinib mesylate, 1a, inhibits production of β-amyloid (Aβ) peptides both in cells and in animal models. It reduces both the β-secretase and γ-secretase cleavages of the amyloid precursor protein (APP)...
4.
Netzer W, Bettayeb K, Sinha S, Flajolet M, Greengard P, Bustos V
Proc Natl Acad Sci U S A
. 2017 Jan;
114(6):1389-1394.
PMID: 28115709
Neurotoxic amyloid-β peptides (Aβ) are major drivers of Alzheimer's disease (AD) and are formed by sequential cleavage of the amyloid precursor protein (APP) by β-secretase (BACE) and γ-secretase. Our previous...
5.
Bettayeb K, Chang J, Luo W, Aryal S, Varotsis D, Randolph L, et al.
Proc Natl Acad Sci U S A
. 2016 Apr;
113(19):5412-7.
PMID: 27114525
The components involved in cellular trafficking and protein recycling machinery that have been associated with increased Alzheimer's disease (AD) risk belong to the late secretory compartments for the most part....
6.
Zhu L, Su M, Lucast L, Liu L, Netzer W, Gandy S, et al.
PLoS One
. 2012 Oct;
7(9):e45033.
PMID: 23024787
Background: Several lines of investigation support the notion that endocytosis is crucial for Alzheimer's disease (AD) pathogenesis. Substantial evidence have already been reported regarding the mechanisms underlying amyloid precursor protein...
7.
He G, Luo W, Li P, Remmers C, Netzer W, Hendrick J, et al.
Nature
. 2010 Sep;
467(7311):95-8.
PMID: 20811458
Accumulation of neurotoxic amyloid-beta is a major hallmark of Alzheimer's disease. Formation of amyloid-beta is catalysed by gamma-secretase, a protease with numerous substrates. Little is known about the molecular mechanisms...
8.
Netzer W, Powell C, Nong Y, Blundell J, Wong L, Duff K, et al.
PLoS One
. 2010 Jun;
5(6):e10943.
PMID: 20532168
beta-amyloid levels are elevated in Down syndrome (DS) patients throughout life and are believed to cause Alzheimer's disease (AD) in adult members of this population. However, it is not known...
9.
Zhang Y, Liu S, Zhang X, Li W, Chen Y, Huang X, et al.
Neuron
. 2009 Nov;
64(3):328-40.
PMID: 19914182
Senile plaques consisting of beta-amyloid (Abeta) and neurofibrillary tangles composed of hyperphosphorylated tau are major pathological hallmarks of Alzheimer's disease (AD). Elucidation of factors that modulate Abeta generation and tau...
10.
Venkitaramani D, Chin J, Netzer W, Gouras G, Lesne S, Malinow R, et al.
J Neurosci
. 2007 Nov;
27(44):11832-7.
PMID: 17978019
No abstract available.