William J McGrath
Overview
Explore the profile of William J McGrath including associated specialties, affiliations and a list of published articles.
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Articles
19
Citations
338
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Recent Articles
1.
Mangel W, McGrath W, Xiong K, Graziano V, Blainey P
Nat Commun
. 2016 Feb;
7:10202.
PMID: 26831565
Recently, we showed the adenovirus proteinase interacts productively with its protein substrates in vitro and in vivo in nascent virus particles via one-dimensional diffusion along the viral DNA. The mechanism...
2.
Geertsema H, Schulte A, Spenkelink L, McGrath W, Morrone S, Sohn J, et al.
Biophys J
. 2015 Feb;
108(4):949-956.
PMID: 25692599
Single-molecule fluorescence microscopy is a powerful tool for observing biomolecular interactions with high spatial and temporal resolution. Detecting fluorescent signals from individual labeled proteins above high levels of background fluorescence...
3.
Perez-Berna A, Mangel W, McGrath W, Graziano V, Flint J, San Martin C
J Virol
. 2013 Nov;
88(3):1513-24.
PMID: 24227847
Late in adenovirus assembly, the viral protease (AVP) becomes activated and cleaves multiple copies of three capsid and three core proteins. Proteolytic maturation is an absolute requirement to render the...
4.
McGrath W, Graziano V, Zabrocka K, Mangel W
FEBS Lett
. 2013 May;
587(15):2332-9.
PMID: 23711373
As there are more than 50 adenovirus serotypes, the likelihood of developing an effective vaccine is low. Here we describe inhibitors of the adenovirus proteinase (AVP) with the ultimate objective...
5.
Baniecki M, McGrath W, Mangel W
J Biol Chem
. 2012 Oct;
288(3):2081-91.
PMID: 23043139
The adenovirus proteinase (AVP), the first member of a new class of cysteine proteinases, is essential for the production of infectious virus, and here we report its structure at 0.98...
6.
Blainey P, Graziano V, Perez-Berna A, McGrath W, Flint S, San Martin C, et al.
J Biol Chem
. 2012 Oct;
288(3):2092-102.
PMID: 23043138
Precursor proteins used in the assembly of adenovirus virions must be processed by the virally encoded adenovirus proteinase (AVP) before the virus particle becomes infectious. An activated adenovirus proteinase, the...
7.
Graziano V, Luo G, Blainey P, Perez-Berna A, McGrath W, Flint S, et al.
J Biol Chem
. 2012 Oct;
288(3):2068-80.
PMID: 23043137
Late in an adenovirus infection, the viral proteinase (AVP) becomes activated to process virion precursor proteins used in virus assembly. AVP is activated by two cofactors, the viral DNA and...
8.
Graziano V, McGrath W, Suomalainen M, Greber U, Freimuth P, Blainey P, et al.
J Biol Chem
. 2012 Oct;
288(3):2059-67.
PMID: 23043136
The precursor to adenovirus protein VI, pVI, is a multifunctional protein with different roles early and late in virus infection. Here, we focus on two roles late in infection, binding...
9.
Mangel W, McGrath W
Methods Mol Med
. 2007 Jul;
131:269-80.
PMID: 17656790
Human adenovirus proteinase (AVP) is required for the synthesis of infectious virus. AVP is synthesized in an inactive form; it is unusual in that it requires cofactors for activation of...
10.
Mangel W, McGrath W
Methods Mol Med
. 2007 Jul;
131:257-67.
PMID: 17656789
Human adenovirus proteinase (AVP), the first member of a new class of cysteine proteinases, is required for the synthesis of infectious virus. As such, it is an attractive target for...