William E Barclay
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Explore the profile of William E Barclay including associated specialties, affiliations and a list of published articles.
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8
Citations
95
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Recent Articles
1.
Gross P, Duran-Laforet V, Ho L, Melchor G, Zia S, Manavi Z, et al.
Nat Commun
. 2025 Mar;
16(1):2283.
PMID: 40055369
The capacity to regenerate myelin in the central nervous system diminishes with age. This decline is particularly evident in multiple sclerosis (MS), a chronic demyelinating disease. Whether cellular senescence, a...
2.
Park E, Barclay W, Barrera A, Liao T, Salzler H, Reddy T, et al.
Sci Immunol
. 2023 Oct;
8(88):eadg7597.
PMID: 37831759
Multiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS) caused by CNS-infiltrating leukocytes, including T17 cells that are critical mediators of disease pathogenesis. Although targeting leukocyte...
3.
Ratiu J, Barclay W, Lin E, Wang Q, Wellford S, Mehta N, et al.
Nat Commun
. 2022 Oct;
13(1):5901.
PMID: 36202870
Production of a functional peripheral T cell compartment typically involves massive expansion of the bone marrow progenitors that seed the thymus. There are two main phases of expansion during T...
4.
Zhang Z, Ma Q, Velagapudi R, Barclay W, Rodriguiz R, Wetsel W, et al.
Front Immunol
. 2022 May;
13:856254.
PMID: 35603196
Neuroinflammation is a growing hallmark of perioperative neurocognitive disorders (PNDs), including delirium and longer-lasting cognitive deficits. We have developed a clinically relevant orthopedic mouse model to study the impact of...
5.
Barclay W, Aggarwal N, Deerhake M, Inoue M, Nonaka T, Nozaki K, et al.
JCI Insight
. 2022 Apr;
7(8).
PMID: 35451371
Inflammasomes are a class of innate immune signaling platforms that activate in response to an array of cellular damage and pathogens. Inflammasomes promote inflammation under many circumstances to enhance immunity...
6.
Deerhake M, Danzaki K, Inoue M, Cardakli E, Nonaka T, Aggarwal N, et al.
Immunity
. 2021 Feb;
54(3):484-498.e8.
PMID: 33581044
Pathologic roles of innate immunity in neurologic disorders are well described, but their beneficial aspects are less understood. Dectin-1, a C-type lectin receptor (CLR), is largely known to induce inflammation....
7.
Khaw Y, Aggarwal N, Barclay W, Kang E, Inoue M, Shinohara M
Front Immunol
. 2020 Nov;
11:529219.
PMID: 33133067
-associated immune reconstitution inflammatory syndrome (C-IRIS) is identified upon immune reconstitution in immunocompromised patients, who have previously contracted an infection of (). C-IRIS can be lethal but how the immune...
8.
Deerhake M, Biswas D, Barclay W, Shinohara M
Front Immunol
. 2019 Nov;
10:2644.
PMID: 31781124
Pattern recognition receptors (PRRs) coordinate the innate immune response and have a significant role in the development of multiple sclerosis (MS). Accumulating evidence has identified both pathogenic and protective functions...
9.
Deerhake M, Barclay W, Shinohara M
Immunity
. 2018 Nov;
49(5):796-798.
PMID: 30462995
Researchers have previously hypothesized autoimmune origins for narcolepsy on the basis of its strong genetic association with an MHC class II allele. In a recent issue of Nature, Latorre et ...