William D Atchison
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Explore the profile of William D Atchison including associated specialties, affiliations and a list of published articles.
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48
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684
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Recent Articles
1.
Yuan Y, Bailey J, Rivera-Lopez G, Atchison W
Neurotoxicology
. 2023 Dec;
100:72-84.
PMID: 38065418
The exact causes of Amyotrophic lateral sclerosis (ALS), a progressive and fatal neurological disorder due to loss of upper and/or lower motoneurons, remain elusive. Gene-environment interactions are believed to be...
2.
Colon-Rodriguez A, Colon-Carrion N, Atchison W
Neurotoxicology
. 2020 Sep;
81:116-126.
PMID: 32991939
α motor neurons (MNs) are a target of the environmental neurotoxicant methylmercury (MeHg), accumulating MeHg and subsequently degenerating. In mouse spinal cord MN cultures, MeHg increased intracellular Ca [Ca]; the...
3.
Sceniak M, Spitsbergen J, Sabo S, Yuan Y, Atchison W
J Neurophysiol
. 2020 Mar;
123(4):1448-1459.
PMID: 32159428
Spinal motor neurons (MNs) are susceptible to glutamatergic excitotoxicity, an effect associated with lumbar MN degeneration in amyotrophic lateral sclerosis (ALS). MN susceptibility to environmental toxicant exposure, one prospective contributor...
4.
Colon-Rodriguez A, Tiernan C, Rodriguez-Tapia E, Atchison W
PLoS One
. 2019 Dec;
14(12):e0225116.
PMID: 31830069
Neuroscience as a discipline is rarely covered in educational institutions in Puerto Rico. In an effort to overcome this deficit we developed the Bridge to Neuroscience Workshop (BNW), a full-day...
5.
Bailey J, Colon-Rodriguez A, Atchison W
Curr Environ Health Rep
. 2017 Apr;
4(2):200-207.
PMID: 28397096
Purpose Of Review: Gene-environment (GxE) interactions likely contribute to numerous diseases, but are often difficult to model in the laboratory. Such interactions have been widely hypothesized for amyotrophic lateral sclerosis...
6.
Colon-Rodriguez A, Hannon H, Atchison W
Neurotoxicology
. 2017 Jan;
60:308-320.
PMID: 28041893
Methylmercury (MeHg) is an environmental neurotoxicant of public health concern. It readily accumulates in exposed humans, primarily in neuronal tissue. Exposure to MeHg, either acutely or chronically, causes severe neuronal...
7.
Tsai T, Yuan Y, Hajela R, Philips S, Atchison W
Neurotoxicology
. 2016 Oct;
60:161-170.
PMID: 27720918
Early onset effects of methylmercury (MeHg) on recombinant αβγ or αβγ subunit-containing GABA receptors were examined. These are two of the most prevalent receptor types found in cerebellum-a consistent target...
8.
Xu Y, Halievski K, Henley C, Atchison W, Katsuno M, Adachi H, et al.
J Neurosci
. 2016 May;
36(18):5094-106.
PMID: 27147661
Unlabelled: Spinal and bulbar muscular atrophy (SBMA) in men is an androgen-dependent neuromuscular disease caused by expanded CAG repeats in the androgen receptor (AR). Whether muscle or motor neuron dysfunction...
9.
Yuan Y, Atchison W
Toxicol Sci
. 2016 Jan;
150(1):117-30.
PMID: 26732885
We previously showed that elevated intracellular Ca(2+) ([Ca(2+)]i) in the molecular layer and granule cells in cerebellar slices is responsible for the initial increases in frequency of spontaneous or miniature...
10.
Bradford A, Mancini J, Atchison W
J Pharmacol Exp Ther
. 2015 Oct;
356(1):2-12.
PMID: 26514794
Methylmercury (MeHg) disrupts cerebellar function, especially during development. Cerebellar granule cells (CGC), which are particularly susceptible to MeHg by unknown mechanisms, migrate during this process. Transient changes in intracellular Ca(2+)...