William C Knowler
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Explore the profile of William C Knowler including associated specialties, affiliations and a list of published articles.
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332
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21545
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Recent Articles
11.
Kim S, Arora I, Hsia D, Knowler W, LeBlanc E, Mylonakis E, et al.
J Clin Endocrinol Metab
. 2023 May;
108(11):e1164-e1174.
PMID: 37207448
There is evidence suggesting that infection with SARS-CoV-2 can lead to several long-term sequelae including diabetes. This mini-review examines the rapidly evolving and conflicting literature on new-onset diabetes after COVID-19,...
12.
Corbin K, Pittas A, Desouza C, Grdinovac K, Herzig K, Kashyap S, et al.
J Diabetes Complications
. 2023 Apr;
37(6):108475.
PMID: 37104979
Aims: Non-alcoholic fatty liver disease (NAFLD) is a common comorbidity that leads to poor outcomes in people at high risk for development of type 2 diabetes (T2D). Vitamin D is...
13.
Ramirez-Luzuriaga M, Kobes S, Sinha M, Knowler W, Hanson R
Am J Epidemiol
. 2023 Apr;
192(8):1304-1314.
PMID: 37083933
Early puberty onset is associated with higher risk of diabetes, but most studies have not accounted for childhood factors that may confound the association. Using data from a study conducted...
14.
Wedekind L, Mahajan A, Hsueh W, Chen P, Olaiya M, Kobes S, et al.
Diabetologia
. 2023 Mar;
66(5):847-860.
PMID: 36862161
Aims/hypothesis: There is limited information on how polygenic scores (PSs), based on variants from genome-wide association studies (GWASs) of type 2 diabetes, add to clinical variables in predicting type 2...
15.
Domalpally A, Whittier S, Pan Q, Dabelea D, Darwin C, Knowler W, et al.
JAMA Ophthalmol
. 2022 Dec;
141(2):140-147.
PMID: 36547967
Importance: Age-related macular degeneration (AMD) is a leading cause of blindness with no treatment available for early stages. Retrospective studies have shown an association between metformin and reduced risk of...
16.
Li J, Perry J, Jablonski K, Srinivasan S, Chen L, Todd J, et al.
Diabetes
. 2022 Dec;
72(8):1161-1172.
PMID: 36525397
Genome-wide significant loci for metformin response in type 2 diabetes reported elsewhere have not been replicated in the Diabetes Prevention Program (DPP). To assess pharmacogenetic interactions in prediabetes, we conducted...
17.
White N, Pan Q, Knowler W, Schroeder E, Dabelea D, Chew E, et al.
Diabetes Care
. 2022 Sep;
45(11):2653-2661.
PMID: 36098658
Objective: To determine glycemic and nonglycemic risk factors that contribute to the presence of diabetic retinopathy (DR) before and after the onset of type 2 diabetes (T2D). Research Design And...
18.
Pena A, Olson M, Hooker E, Ayers S, Castro F, Patrick D, et al.
JAMA Netw Open
. 2022 Sep;
5(9):e2231196.
PMID: 36094502
Importance: Latino youths are disproportionately impacted by prediabetes and type 2 diabetes (T2D). Lifestyle intervention is the first-line approach for preventing or delaying T2D among adults with prediabetes. Objective: To...
19.
Arreola E, Knowler W, Hanson R
J Clin Endocrinol Metab
. 2022 Sep;
107(11):3086-3099.
PMID: 36062951
Context: Insulin secretion and sensitivity regulate glycemia, with inadequately compensated deficiencies leading to diabetes. Objective: We investigated effects of weight loss, an intensive lifestyle intervention (ILS), and metformin on the...
20.
Muller Y, Saporito M, Day S, Bandesh K, Koroglu C, Kobes S, et al.
Eur J Hum Genet
. 2022 Jun;
30(10):1159-1166.
PMID: 35688891
Insulin-like growth factor binding protein 4 (IGFBP4) is involved in adipogenesis, and IGFBP4 null mice have decreased body fat through decreased PPAR-γ expression. In the current study, we assessed whether...