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William Arthur

Explore the profile of William Arthur including associated specialties, affiliations and a list of published articles. Areas
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Articles 5
Citations 307
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Recent Articles
1.
Dotson B, Larabell P, Patel J, Wong K, Qasem L, Arthur W, et al.
Pharmacotherapy . 2016 Oct; 36(11):1185-1190. PMID: 27732742
Study Objective: Parenteral calcium is frequently administered to critically ill patients. However, animal studies demonstrate that calcium administration during critical illness heightens inflammation and leads to shock, organ dysfunction, and...
2.
ONeil J, Benita Y, Feldman I, Chenard M, Roberts B, Liu Y, et al.
Mol Cancer Ther . 2016 Mar; 15(6):1155-62. PMID: 26983881
Combination drug therapy is a widely used paradigm for managing numerous human malignancies. In cancer treatment, additive and/or synergistic drug combinations can convert weakly efficacious monotherapies into regimens that produce...
3.
Andersen J, Sathyanarayanan S, Di Bacco A, Chi A, Zhang T, Chen A, et al.
Sci Transl Med . 2010 Aug; 2(43):43ra55. PMID: 20686178
Although we have made great progress in understanding the complex genetic alterations that underlie human cancer, it has proven difficult to identify which molecularly targeted therapeutics will benefit which patients....
4.
Loboda A, Nebozhyn M, Klinghoffer R, Frazier J, Chastain M, Arthur W, et al.
BMC Med Genomics . 2010 Jul; 3:26. PMID: 20591134
Background: Hyperactivation of the Ras signaling pathway is a driver of many cancers, and RAS pathway activation can predict response to targeted therapies. Therefore, optimal methods for measuring Ras pathway...
5.
Chung N, Marine S, Smith E, Liehr R, Smith S, Locco L, et al.
Assay Drug Dev Technol . 2010 Jun; 8(3):286-94. PMID: 20578927
High-throughput siRNA screens are now widely used for identifying novel drug targets and mapping disease pathways. Despite their popularity, there remain challenges related to data variability, primarily due to measurement...