Will Kaplan
Overview
Explore the profile of Will Kaplan including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
5
Citations
56
Followers
0
Related Specialty
Related Specialty
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Logan K, Kaplan W, Simov V, Zhou H, Li D, Torres L, et al.
J Med Chem
. 2024 Sep;
67(18):16807-16819.
PMID: 39231262
Inhibition of leucine-rich repeat kinase 2 is a genetically supported mechanism for the treatment of Parkinson's disease. We previously disclosed the discovery of an indazole series lead that demonstrated both...
2.
Khatri H, Bhattarai B, Kaplan W, Li Z, Long M, Aye Y, et al.
J Am Chem Soc
. 2019 Feb;
141(12):4849-4860.
PMID: 30802047
A Cu(II)-catalyzed diastereoselective Michael/aldol cascade approach is used to accomplish concise total syntheses of cardiotonic steroids with varying degrees of oxygenation including cardenolides ouabagenin, sarmentologenin, 19-hydroxysarmentogenin, and 5- epi-panogenin. These...
3.
Kaplan W, Khatri H, Nagorny P
J Am Chem Soc
. 2016 May;
138(22):7194-8.
PMID: 27232585
The expedient and scalable approach to cardiotonic steroids carrying oxygenation at the C11- and C19-positions has been developed and applied to the total asymmetric synthesis of steroids 19-hydroxysarmentogenin and trewianin...
4.
Cichowicz N, Kaplan W, Khomutnyk Y, Bhattarai B, Sun Z, Nagorny P
J Am Chem Soc
. 2015 Oct;
137(45):14341-8.
PMID: 26491886
A new scalable enantioselective approach to functionalized oxygenated steroids is described. This strategy is based on chiral bis(oxazoline) copper(II) complex-catalyzed enantioselective and diastereoselective Michael reactions of cyclic ketoesters and enones...
5.
Mensah E, Camasso N, Kaplan W, Nagorny P
Angew Chem Int Ed Engl
. 2013 Oct;
52(49):12932-6.
PMID: 24123751
In control: A chiral phosphoric acid catalyst significantly enhances or completely overrides the inherent regioselective acetalization profiles exhibited by monosaccharide-derived 1,2-diol substrates. This study represents the first example of chiral-catalyst-directed...