Wilhelmina M Huston
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Explore the profile of Wilhelmina M Huston including associated specialties, affiliations and a list of published articles.
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85
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1201
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Recent Articles
1.
Wong A, Lima N, Applegate T, Guy R, Huston W, Hocking J, et al.
Clin Infect Dis
. 2024 Aug;
PMID: 39102890
Background: Modern assays for the detection of Chlamydia trachomatis (CT) rely on nucleic acid amplification testing (NAAT) of DNA or ribosomal RNA. However, it is also known that both viable...
2.
Phillips M, Huston W, McDonagh A, Rawling T
Molecules
. 2024 Apr;
29(7).
PMID: 38611800
4-Chloroisocoumarin compounds have broad inhibitory properties against serine proteases. Here, we show that selected 3-alkoxy-4-chloroisocoumarins preferentially inhibit the activity of the conserved serine protease High-temperature requirement A of . The...
3.
Strange N, Luu L, Ong V, Wee B, Phillips M, McCaughey L, et al.
J Bacteriol
. 2024 Mar;
206(4):e0037123.
PMID: 38445896
Importance: is an important obligate intracellular pathogen that has a unique biphasic developmental cycle. HtrA is an essential stress or virulence protease in many bacteria, with many different functions. Previously,...
4.
IgG exacerbates genital chlamydial pathology in females by enhancing pathogenic CD8 T cell responses
Armitage C, OMeara C, Bryan E, Kollipara A, Trim L, Hickey D, et al.
Scand J Immunol
. 2024 Mar;
99(1):e13331.
PMID: 38441219
Chlamydia trachomatis infections are an important sexually transmitted infection that can lead to inflammation, scarring and hydrosalpinx/infertility. However, infections are commonly clinically asymptomatic and do not receive treatment. The underlying...
5.
Jury B, Fleming C, Huston W, Luu L
Front Cell Infect Microbiol
. 2024 Jan;
13:1358553.
PMID: 38249301
[This corrects the article DOI: 10.3389/fcimb.2023.1281823.].
6.
Jury B, Fleming C, Huston W, Luu L
Front Cell Infect Microbiol
. 2023 Nov;
13:1281823.
PMID: 37920447
is a strict intracellular human pathogen. It is the main bacterial cause of sexually transmitted infections and the etiologic agent of trachoma, which is the leading cause of preventable blindness....
7.
8.
Huston W, Lawrence A, Wee B, Thomas M, Timms P, Vodstrcil L, et al.
Front Public Health
. 2022 Oct;
10:1012835.
PMID: 36299763
, the most common bacterial sexually transmitted infection worldwide, is responsible for considerable health burden due to its significant sequelae. There are growing concerns about chlamydial treatment and management due...
9.
Bittleston H, Hocking J, Goller J, Coombe J, Bateson D, Sweeney S, et al.
PLoS One
. 2022 Sep;
17(9):e0274666.
PMID: 36121793
Introduction: There is currently no test for pelvic inflammatory disease (PID) that is non-invasive and sufficiently sensitive and specific. Clinicians must therefore diagnose PID clinically, ruling out medical emergencies and...
10.
Hwang J, Strange N, Mazraani R, Phillips M, Gamble A, Huston W, et al.
Eur J Med Chem
. 2022 Jan;
230:114064.
PMID: 35007862
High temperature requirement A (HtrA) serine proteases have emerged as a novel class of antibacterial target, which are crucial in protein quality control and are involved in the pathogenesis of...