Wilfred A Jefferies
Overview
Explore the profile of Wilfred A Jefferies including associated specialties, affiliations and a list of published articles.
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Articles
67
Citations
1751
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Recent Articles
1.
Caspani G, Ruffell S, Tsang W, Netzband N, Rohani-Shukla C, Swann J, et al.
Pharmacol Res
. 2024 Aug;
207:107338.
PMID: 39111558
Psychedelics have emerged as promising therapeutics for several psychiatric disorders. Hypotheses around their mechanisms have revolved around their partial agonism at the serotonin 2 A receptor, leading to enhanced neuroplasticity...
2.
Singh C, Johns K, Kari S, Munro L, Mathews A, Fenninger F, et al.
Stem Cell Reports
. 2024 Mar;
19(4):456-468.
PMID: 38552634
The risk of iatrogenic disease is often underestimated as a concern in contemporary medical procedures, encompassing tissue and organ transplantation, stem cell therapies, blood transfusions, and the administration of blood-derived...
3.
Saranchova I, Xia C, Besoiu S, Finkel P, Ellis S, Kari S, et al.
Front Immunol
. 2024 Mar;
15:1317522.
PMID: 38524132
Cell-based cancer immunotherapy has achieved significant advancements, providing a source of hope for cancer patients. Notwithstanding the considerable progress in cell-based immunotherapy, the persistently low response rates and the exorbitant...
4.
Xia C, Saranchova I, Finkel P, Besoiu S, Munro L, Pfeifer C, et al.
Commun Biol
. 2024 Jan;
7(1):12.
PMID: 38172434
Type 2 innate lymphoid cells (ILC2s) perform vital functions in orchestrating humoral immune responses, facilitating tissue remodelling, and ensuring tissue homeostasis. Additionally, in a role that has garnered considerably less...
5.
Ellis S, Dada S, Nohara L, Saranchova I, Munro L, Pfeifer C, et al.
Front Pharmacol
. 2023 Aug;
14:1119620.
PMID: 37637416
Curcuphenol, a common component of the culinary spices, naturally found in marine invertebrates and plants, has been identified as a novel candidate for reversing immune escape by restoring expression of...
6.
Eyford B, Lazarczyk M, Choi K, Varghese M, Arora H, Kari S, et al.
Sci Rep
. 2023 Aug;
13(1):13079.
PMID: 37567897
The interplay between AMPA-type glutamate receptors (AMPARs) and major histocompatibility complex class I (MHC-I) proteins in regulating synaptic signaling is a crucial aspect of central nervous system (CNS) function. In...
7.
Nohara L, Ellis S, Dreier C, Dada S, Saranchova I, Bok Choi K, et al.
Front Pharmacol
. 2023 May;
14:1119607.
PMID: 37256225
Genetic and epigenetic events have been implicated in the downregulation of the cellular antigen processing and presentation machinery (APM), which in turn, has been associated with cancer evasion of the...
8.
Lazarczyk M, Eyford B, Varghese M, Arora H, Munro L, Warda T, et al.
Sci Rep
. 2023 Apr;
13(1):6448.
PMID: 37081001
Major histocompatibility complex class I (MHC-I) proteins are expressed in neurons, where they regulate synaptic plasticity. However, the mechanisms by which MHC-I functions in the CNS remains unknown. Here we...
9.
Dada S, Ellis S, Wood C, Nohara L, Dreier C, Garcia N, et al.
Front Immunol
. 2023 Mar;
13:982082.
PMID: 36923728
Emerging cancers are sculpted by neo-Darwinian selection for superior growth and survival but minimal immunogenicity; consequently, metastatic cancers often evolve common genetic and epigenetic signatures to elude immune surveillance. Immune...
10.
Stanwood S, Chong L, Steidl C, Jefferies W
Front Pharmacol
. 2022 Jun;
13:795176.
PMID: 35685639
Cell surface calcium (Ca) channels permit Ca ion influx, with Ca taking part in cellular functions such as proliferation, survival, and activation. The expression of voltage-dependent Ca (Ca) channels may...