Wieland B Huttner
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Explore the profile of Wieland B Huttner including associated specialties, affiliations and a list of published articles.
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190
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12158
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Recent Articles
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Namba T, Huttner W
Annu Rev Cell Dev Biol
. 2024 Oct;
40(1):427-452.
PMID: 39356810
"What makes us human?" is a central question of many research fields, notably anthropology. In this review, we focus on the development of the human neocortex, the part of the...
3.
Role of cell metabolism in the pathophysiology of brain size-associated neurodevelopmental disorders
Xing L, Huttner W, Namba T
Neurobiol Dis
. 2024 Jul;
199:106607.
PMID: 39029564
Cell metabolism is a key regulator of human neocortex development and evolution. Several lines of evidence indicate that alterations in neural stem/progenitor cell (NPC) metabolism lead to abnormal brain development,...
4.
Xing L, Gkini V, Nieminen A, Zhou H, Aquilino M, Naumann R, et al.
Nat Commun
. 2024 Apr;
15(1):3468.
PMID: 38658571
Metabolism has recently emerged as a major target of genes implicated in the evolutionary expansion of human neocortex. One such gene is the human-specific gene ARHGAP11B. During human neocortex development,...
5.
Wilsch-Brauninger M, Peters J, Huttner W
Front Cell Dev Biol
. 2024 Mar;
12:1344734.
PMID: 38500687
The development of the neocortex involves an interplay between neural cells and the vasculature. However, little is known about this interplay at the ultrastructural level. To gain a 3D insight...
6.
Dehay C, Huttner W
Development
. 2024 Feb;
151(4).
PMID: 38369736
The generation of neurons in the developing neocortex is a major determinant of neocortex size. Crucially, the increase in cortical neuron numbers in the primate lineage, notably in the upper-layer...
7.
Huttner W, Heide M, Mora-Bermudez F, Namba T
J Comp Neurol
. 2024 Jan;
532(2):e25576.
PMID: 38189676
In this review, we focus on human-specific features of neocortical neurogenesis in development and evolution. Two distinct topics will be addressed. In the first section, we discuss the expansion of...
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Luppi A, Girn M, Rosas F, Timmermann C, Roseman L, Erritzoe D, et al.
Brain
. 2023 Sep;
147(1):56-80.
PMID: 37703310
Integrating independent but converging lines of research on brain function and neurodevelopment across scales, this article proposes that serotonin 2A receptor (5-HT2AR) signalling is an evolutionary and developmental driver and...
10.
Tynianskaia L, Esiyok N, Huttner W, Heide M
J Vis Exp
. 2023 Apr;
(193).
PMID: 37036224
The cerebral cortex is the outermost brain structure and is responsible for the processing of sensory input and motor output; it is seen as the seat of higher-order cognitive abilities...