Wieland B Huttner
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Explore the profile of Wieland B Huttner including associated specialties, affiliations and a list of published articles.
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Recent Articles
11.
Pinson A, Maricic T, Zeberg H, Paabo S, Huttner W
Science
. 2023 Mar;
379(6636):eadf2212.
PMID: 36893240
Herai . discuss the known fact that a low percentage of modern humans who lack any overt phenotypes carry the ancestral allele. Our paper demonstrates that the amino acid substitution...
12.
Zhang K, Da Silva F, Seidl C, Wilsch-Brauninger M, Herbst J, Huttner W, et al.
Dev Cell
. 2023 Jan;
58(2):139-154.e8.
PMID: 36693320
WNT signaling is important in development, stem cell maintenance, and disease. WNT ligands typically signal via receptor activation across the plasma membrane to induce β-catenin-dependent gene activation. Here, we show...
13.
Fischer J, Ortuno E, Marsoner F, Artioli A, Peters J, Namba T, et al.
EMBO Rep
. 2022 Sep;
23(11):e54728.
PMID: 36098218
The human-specific gene ARHGAP11B has been implicated in human neocortex expansion. However, the extent of ARHGAP11B's contribution to this expansion during hominid evolution is unknown. Here we address this issue...
14.
Pinson A, Xing L, Namba T, Kalebic N, Peters J, Eugster Oegema C, et al.
Science
. 2022 Sep;
377(6611):eabl6422.
PMID: 36074851
Neanderthal brains were similar in size to those of modern humans. We sought to investigate potential differences in neurogenesis during neocortex development. Modern human transketolase-like 1 (TKTL1) differs from Neanderthal...
15.
Mora-Bermudez F, Kanis P, Macak D, Peters J, Naumann R, Xing L, et al.
Sci Adv
. 2022 Jul;
8(30):eabn7702.
PMID: 35905187
Since the ancestors of modern humans separated from those of Neanderthals, around 100 amino acid substitutions spread to essentially all modern humans. The biological significance of these changes is largely...
16.
Vaid S, Huttner W
Front Cell Dev Biol
. 2022 May;
10:892922.
PMID: 35602606
During development, the decision of stem and progenitor cells to switch from proliferation to differentiation is of critical importance for the overall size of an organ. Too early a switch...
17.
Mora-Bermudez F, Huttner W
Front Neurosci
. 2022 May;
16:878950.
PMID: 35495057
When considering what makes us human, the development of the neocortex, the seat of our higher cognitive abilities, is of central importance. Throughout this complex developmental process, neocortical stem and...
18.
Long K, Huttner W
Front Cell Neurosci
. 2022 Feb;
15:804649.
PMID: 35140590
Extracellular matrix (ECM) has long been known to regulate many aspects of neural development in many different species. However, the role of the ECM in the development of the human...
19.
Wilsch-Brauninger M, Huttner W
Front Neurosci
. 2021 Nov;
15:755867.
PMID: 34744618
During mammalian brain development, neural stem and progenitor cells generate the neurons for the six-layered neocortex. The proliferative capacity of the different types of progenitor cells within the germinal zones...
20.
Kerimoglu C, Pham L, Tonchev A, Sakib M, Xie Y, Sokpor G, et al.
Sci Adv
. 2021 Sep;
7(38):eabc6792.
PMID: 34524839
Increase in the size of human neocortex―acquired in evolution―accounts for the unique cognitive capacity of humans. This expansion reflects the evolutionarily enhanced proliferative ability of basal progenitors (BPs), including the...