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Wiebke Hansen

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Articles 85
Citations 2057
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Recent Articles
1.
Llovera G, Langhauser F, Isla Cainzos S, Hoppen M, Abberger H, Mohamud Yusuf A, et al.
Stroke . 2024 Sep; 55(10):2522-2527. PMID: 39315830
Background: The discrepancy between experimental research and clinical trial outcomes is a persistent challenge in preclinical studies, particularly in stroke research. A possible factor contributing to this issue is the...
2.
Ninnemann A, Hock K, Luppus S, Scherbaum N, Temme C, Buer J, et al.
Int Immunopharmacol . 2024 Aug; 140:112736. PMID: 39088925
Opioid addiction presents a relevant health challenge, with chronic heroin use linked to detrimental effects on various aspects of physical, mental, and sociological health. Opioid maintenance therapy (OMT), particularly using...
3.
Haupeltshofer S, Mencl S, Szepanowski R, Hansmann C, Casas A, Abberger H, et al.
J Neuroinflammation . 2024 Jun; 21(1):155. PMID: 38872149
Activation of the kallikrein-kinin system promotes vascular leakage, inflammation, and neurodegeneration in ischemic stroke. Inhibition of plasma kallikrein (PK) - a key component of the KKS - in the acute...
4.
Kohler A, Geiselhoringer A, Kolland D, Kreft L, Wichmann N, Hils M, et al.
Mucosal Immunol . 2024 Apr; 17(4):673-691. PMID: 38663461
Peripherally-induced regulatory T cells (pTregs) expressing the retinoic acid receptor-related orphan-receptor gamma t (RORγt) are indispensable for intestinal immune homeostasis. Nuclear factor kappa family members regulate the differentiation of thymic...
5.
Steinbach P, Pastille E, Kaumanns L, Adamczyk A, Sutter K, Hansen W, et al.
PLoS Pathog . 2024 Jan; 20(1):e1011982. PMID: 38271469
Influenza A virus (IAV) can cause severe respiratory infection leading to significant global morbidity and mortality through seasonal epidemics. Likewise, the constantly increasing number of cancer diseases is a growing...
6.
Abberger H, Hose M, Ninnemann A, Menne C, Eilbrecht M, Lang K, et al.
PLoS Pathog . 2023 Nov; 19(11):e1011837. PMID: 38019895
Neuropilin-1 (Nrp-1) expression on CD8+ T cells has been identified in tumor-infiltrating lymphocytes and in persistent murine gamma-herpes virus infections, where it interferes with the development of long-lived memory T...
7.
Podschwadt P, Malyshkina A, Windmann S, Papadamakis A, Kerkmann L, Lapuente D, et al.
Front Immunol . 2023 Jan; 13:934399. PMID: 36605206
Retroviral envelope (Env) proteins have long been recognized to exhibit immunosuppressive properties, which affect the CD8 T-cell response to an infection but also to immunization. Interestingly, we previously showed in...
8.
Podschwadt P, Malyshkina A, Windmann S, Werner T, Hansen W, Bayer W
Retrovirology . 2022 Dec; 19(1):29. PMID: 36527061
Background: Friend virus (FV) is a complex of the Friend murine leukemia virus (F-MuLV) and the replication-defective, pathogenic spleen focus forming virus (SFFV). In the past, we used a fluorescently...
9.
Hose M, Gunther A, Naser E, Schumacher F, Schonberger T, Falkenstein J, et al.
Elife . 2022 Nov; 11. PMID: 36426850
Acid sphingomyelinase (Asm) and acid ceramidase (Ac) are parts of the sphingolipid metabolism. Asm hydrolyzes sphingomyelin to ceramide, which is further metabolized to sphingosine by Ac. Ceramide generates ceramide-enriched platforms...
10.
Gunther A, Hose M, Abberger H, Schumacher F, Veith Y, Kleuser B, et al.
Elife . 2022 Sep; 11. PMID: 36094170
Acid ceramidase (Ac) is part of the sphingolipid metabolism and responsible for the degradation of ceramide. As bioactive molecule, ceramide is involved in the regulation of many cellular processes. However,...