Wessam Abdelhady
Overview
Explore the profile of Wessam Abdelhady including associated specialties, affiliations and a list of published articles.
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Articles
21
Citations
330
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Recent Articles
1.
Li Y, Berti A, Abdelhady W, Xiong Y
Antibiotics (Basel)
. 2025 Feb;
14(2).
PMID: 40001434
Persistent methicillin-resistant (MRSA) endovascular infections present a significant clinical therapeutic challenge. Prophages are increasingly recognized as important genetic factors influencing the pathogenicity of , yet their role in antibiotic persistence...
2.
Sauve K, Watson A, Oh J, Swift S, Vila-Farres X, Abdelhady W, et al.
J Infect Dis
. 2024 Feb;
230(2):309-318.
PMID: 38366561
Background: Lysins (cell wall hydrolases) targeting gram-negative organisms require engineering to permeabilize the outer membrane and access subjacent peptidoglycan to facilitate killing. In the current study, the potential clinical utility...
3.
Ersoy S, Proctor R, Rose W, Abdelhady W, Fan S, Madrigal S, et al.
Antimicrob Agents Chemother
. 2024 Feb;
68(3):e0162723.
PMID: 38349162
Methicillin-resistant (MRSA) strains are a major challenge for clinicians due, in part, to their resistance to most β-lactams, the first-line treatment for methicillin-susceptible . A phenotype termed "NaHCO-responsiveness" has been...
4.
Xiong Y, Li Y, Goncheva M, Elsayed A, Zhu F, Li L, et al.
J Infect Dis
. 2024 Feb;
229(6):1648-1657.
PMID: 38297970
Background: Staphylococcus aureus is the most common cause of life-threatening endovascular infections, including infective endocarditis (IE). These infections, especially when caused by methicillin-resistant strains (MRSA), feature limited therapeutic options and...
5.
Mishra N, Abdelhady W, Elsayed A, Lapitan C, Proctor R, Rybak M, et al.
Antimicrob Agents Chemother
. 2023 Mar;
67(4):e0147222.
PMID: 36877026
The Streptococcus mitis subgroup of the viridans group streptococci (VGS) are the most common cause of infective endocarditis (IE) in many parts of the world. These organisms are frequently resistant...
6.
Mishra N, Lew C, Abdelhady W, Lapitan C, Proctor R, Rose W, et al.
Antimicrob Agents Chemother
. 2021 Oct;
66(1):e0164921.
PMID: 34694870
Increased usage of daptomycin (DAP) for methicillin-resistant Staphylococcus aureus (MRSA) infections has led to emergence of DAP-resistant (DAP-R) strains, resulting in treatment failures. DAP-fosfomycin (Fosfo) combinations are synergistically active against...
7.
Huang D, Gaukel E, Kerzee N, Borroto-Esoda K, Lowry S, Xiong Y, et al.
Antimicrob Agents Chemother
. 2021 Jun;
65(8):e0050821.
PMID: 34097491
We utilized the rabbit model of aortic valve infective endocarditis to examine the combined efficacy of the lysin LSVT-1701 plus daptomycin. The combination of LSVT-1701 plus daptomycin was highly effective...
8.
Shah S, Xiong Y, Abdelhady W, Iwaz J, Pak Y, Schuch R, et al.
Antimicrob Agents Chemother
. 2020 Apr;
64(7).
PMID: 32340988
Methicillin-resistant (MRSA) poses significant therapeutic challenges related to its frequency in clinical infections, innate virulence properties, and propensity for multiantibiotic resistance. MRSA is among the most common causes of endovascular...
9.
Li L, Bayer A, Cheung A, Lu L, Abdelhady W, Donegan N, et al.
J Infect Dis
. 2020 Apr;
222(7):1188-1198.
PMID: 32333768
Persistent methicillin-resistant Staphylococcus aureus (MRSA) endovascular infections represent a significant clinical-therapeutic challenge. Of particular concern is antibiotic treatment failure in infections caused by MRSA that are "susceptible" to antibiotic in...
10.
Li L, Wang G, Cheung A, Abdelhady W, Seidl K, Xiong Y
J Infect Dis
. 2019 Jun;
220(6):1019-1028.
PMID: 31177268
Background: MgrA is an important global virulence gene regulator in Staphylococcus aureus. In the present study, the role of mgrA in host-pathogen interactions related to virulence was explored in both...