Wenlei Peng
Overview
Explore the profile of Wenlei Peng including associated specialties, affiliations and a list of published articles.
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21
Citations
624
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Recent Articles
1.
Malki Y, Kang G, Lam W, Lam W, Zhou Q, Cheng S, et al.
Genome Res
. 2024 Nov;
35(1):31-42.
PMID: 39603706
The concentration of circulating cell-free DNA (cfDNA) in plasma is an important determinant of the robustness of liquid biopsies. However, biological mechanisms that lead to inter-individual differences in cfDNA concentrations...
2.
Zhu G, Jiang P, Li X, Peng W, Choy L, Yu S, et al.
Clin Chem
. 2024 Aug;
70(11):1355-1365.
PMID: 39206580
Background: Cell-free DNA (cfDNA) analysis offers an attractive noninvasive means of detecting and monitoring diseases. cfDNA cleavage patterns within a short range (e.g., 11 nucleotides) have been reported to correlate...
3.
Che H, Jiang P, Choy L, Cheng S, Peng W, Chan R, et al.
Genome Res
. 2024 Feb;
34(2):189-200.
PMID: 38408788
Recent studies have revealed an unexplored population of long cell-free DNA (cfDNA) molecules in human plasma using long-read sequencing technologies. However, the biological properties of long cfDNA molecules (>500 bp)...
4.
Gai W, Yu S, Chan W, Peng W, Lau S, Leung T, et al.
Prenat Diagn
. 2023 Sep;
43(11):1385-1393.
PMID: 37655424
Objective: Long cell-free DNA (cfDNA) can be found in the plasma of pregnant women and cancer patients. We investigated if droplet digital PCR (ddPCR) can analyze such molecules for diagnostic...
5.
Zeng H, Shi N, Peng W, Yang Q, Ren J, Yang H, et al.
Molecules
. 2023 Jul;
28(13).
PMID: 37446918
Obesity represents a major health challenge because it substantially increases the risk of metabolic diseases. Capsaicin, the major active ingredient of spp., has been reported to possess anti-obesity activity. Hereon,...
6.
Zhou Z, Ma M, Chan R, Lam W, Peng W, Gai W, et al.
Proc Natl Acad Sci U S A
. 2023 Apr;
120(17):e2220982120.
PMID: 37075072
Cell-free DNA (cfDNA) fragmentation is nonrandom, at least partially mediated by various DNA nucleases, forming characteristic cfDNA end motifs. However, there is a paucity of tools for deciphering the relative...
7.
Yu S, Deng J, Qiao R, Cheng S, Peng W, Lau S, et al.
Clin Chem
. 2022 Nov;
69(2):168-179.
PMID: 36322427
Background: Recent studies using single molecule, real-time (SMRT) sequencing revealed a substantial population of analyzable long cell-free DNA (cfDNA) in plasma. Potential clinical utilities of such long cfDNA in pregnancy...
8.
Zhou Q, Kang G, Jiang P, Qiao R, Lam W, Yu S, et al.
Proc Natl Acad Sci U S A
. 2022 Oct;
119(44):e2209852119.
PMID: 36288287
Cell-free DNA (cfDNA) fragmentation patterns contain important molecular information linked to tissues of origin. We explored the possibility of using fragmentation patterns to predict cytosine-phosphate-guanine (CpG) methylation of cfDNA, obviating...
9.
Choy L, Peng W, Jiang P, Cheng S, Yu S, Shang H, et al.
Clin Chem
. 2022 May;
68(9):1151-1163.
PMID: 35587130
Background: Analysis of circulating tumor DNA has become increasingly important as a tool for cancer care. However, the focus of previous studies has been on short fragments of DNA. Also,...
10.
Ding S, Chan R, Peng W, Huang L, Zhou Z, Hu X, et al.
Clin Chem
. 2022 May;
68(7):917-926.
PMID: 35587043
Background: Jagged ends of plasma DNA are a recently recognized class of fragmentomic markers for cell-free DNA, reflecting the activity of nucleases. A number of recent studies have also highlighted...