Wenfeng An
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Explore the profile of Wenfeng An including associated specialties, affiliations and a list of published articles.
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37
Citations
853
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Recent Articles
11.
Wang Z, McSwiggin H, Newkirk S, Wang Y, Oliver D, Tang C, et al.
Mob DNA
. 2019 May;
10:17.
PMID: 31073336
Background: Transposable elements (TEs) make up > 50% of the human genome, and the majority of retrotransposon insertions are truncated and many are located in introns. However, the effects of...
12.
Reznik B, Cincotta S, Jaszczak R, Mateo L, Shen J, Cao M, et al.
Development
. 2019 Jan;
146(12).
PMID: 30658985
Epigenetic resetting in germ cells during development de-represses transposable elements (TEs). piRNAs protect fetal germ cells by targeted mRNA destruction and deposition of repressive epigenetic marks. Here, we provide the...
13.
Kawano K, Doucet A, Ueno M, Kariya R, An W, Marzetta F, et al.
Nucleic Acids Res
. 2018 Aug;
46(16):8454-8470.
PMID: 30085096
Long interspersed element-1 (LINE-1, L1) composes ∼17% of the human genome. However, genetic interactions between L1 and human immunodeficiency virus type 1 (HIV-1) remain poorly understood. In this study, we...
14.
Sheng Z, Liu R, Yu J, Ran Z, Newkirk S, An W, et al.
J Gen Virol
. 2018 Feb;
99(4):475-488.
PMID: 29458654
Influenza B virus (FLUBV) is an important pathogen that infects humans and causes seasonal influenza epidemics. To date, little is known about defective genomes of FLUBV and their roles in...
15.
Newkirk S, Lee S, Grandi F, Gaysinskaya V, Rosser J, Vanden Berg N, et al.
Proc Natl Acad Sci U S A
. 2017 Jun;
114(28):E5635-E5644.
PMID: 28630288
The PIWI-interacting RNA (piRNA) pathway is essential for retrotransposon silencing. In piRNA-deficient mice, L1-overexpressing male germ cells exhibit excessive DNA damage and meiotic defects. It remains unknown whether L1 expression...
16.
Kannan M, Li J, Fritz S, Husarek K, Sanford J, Sullivan T, et al.
Mob DNA
. 2017 May;
8:8.
PMID: 28491150
Background: The ongoing mobilization of mammalian transposable elements (TEs) contributes to natural genetic variation. To survey the epigenetic control and expression of reporter genes inserted by L1 retrotransposition in diverse...
17.
Kharytonchyk S, King S, Ndongmo C, Stilger K, An W, Telesnitsky A
J Mol Biol
. 2016 Apr;
428(11):2275-2288.
PMID: 27075671
A key contributor to HIV-1 genetic variation is reverse transcriptase errors. Some mutations result because reverse transcriptase (RT) lacks 3' to 5' proofreading exonuclease and can extend mismatches. However, RT...
18.
Grandi F, Rosser J, Newkirk S, Yin J, Jiang X, Xing Z, et al.
Genome Res
. 2015 May;
25(8):1135-46.
PMID: 25995269
Long interspersed elements (LINEs), through both self-mobilization and trans-mobilization of short interspersed elements and processed pseudogenes, have made an indelible impact on the structure and function of the human genome....
19.
Grandi F, An W
Mob Genet Elements
. 2013 Nov;
3(4):e25674.
PMID: 24195012
The human genome is laden with both non-LTR (long-terminal repeat) retrotransposons and microsatellite repeats. Both types of sequences are able to, either actively or passively, mutagenize the genomes of human...
20.
ODonnell K, An W, Schrum C, Wheelan S, Boeke J
Proc Natl Acad Sci U S A
. 2013 Jul;
110(29):E2706-13.
PMID: 23818630
A codon-optimized mouse LINE-1 element, ORFeus, exhibits dramatically higher retrotransposition frequencies compared with its native long interspersed element 1 counterpart. To establish a retrotransposon-mediated mouse model with regulatable and potent...