Wendy Richmond
Overview
Explore the profile of Wendy Richmond including associated specialties, affiliations and a list of published articles.
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Articles
12
Citations
451
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0
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Recent Articles
1.
Koester D, Marx V, Williams S, Jiricek J, Dauphinais M, Rene O, et al.
J Med Chem
. 2022 Aug;
65(17):11776-11787.
PMID: 35993839
Human African Trypanosomiasis (HAT) is a vector-borne disease caused by kinetoplastid parasites of the genus. The disease proceeds in two stages, with a hemolymphatic blood stage and a meningo-encephalic brain...
2.
Alper P, Deane J, Betschart C, Buffet D, Collignon Zipfel G, Gordon P, et al.
Bioorg Med Chem Lett
. 2020 Aug;
30(17):127366.
PMID: 32738975
Antagonism of the Toll-like receptors (TLRs) 7 and TLR8 has been hypothesized to be beneficial to patients suffering from autoimmune conditions. A phenotypic screen for small molecule antagonists of TLR7/8...
3.
Nagle A, Biggart A, Be C, Srinivas H, Hein A, Caridha D, et al.
J Med Chem
. 2020 Jul;
63(19):10773-10781.
PMID: 32667203
Visceral leishmaniasis is responsible for up to 30,000 deaths every year. Current treatments have shortcomings that include toxicity and variable efficacy across endemic regions. Previously, we reported the discovery of...
4.
Chianelli D, Rucker P, Roland J, Tully D, Nelson J, Liu X, et al.
J Med Chem
. 2020 Jan;
63(8):3868-3880.
PMID: 31940200
Farnesoid X receptor (FXR) agonists are emerging as important potential therapeutics for the treatment of nonalcoholic steatohepatitis (NASH) patients, as they exert positive effects on multiple aspects of the disease....
5.
Liu B, Gordon W, Richmond W, Groessl T, Tuntland T
Eur J Pharm Sci
. 2015 Oct;
87:52-7.
PMID: 26499309
The aim of the present study was to determine whether Cremophor EL is a suitable surfactant that can be routinely applied to pharmacokinetic (PK) studies in early drug discovery without...
6.
Phillips D, Gao W, Yang Y, Zhang G, Lerario I, Lau T, et al.
J Med Chem
. 2014 Mar;
57(8):3263-82.
PMID: 24666203
Activation of the G-protein coupled receptor (GPCR) Takeda G-protein receptor 5 (TGR5), also known as G-protein bile acid receptor 1 (GPBAR1), has been shown to play a key role in...
7.
Marsilje T, Pei W, Chen B, Lu W, Uno T, Jin Y, et al.
J Med Chem
. 2013 Jun;
56(14):5675-90.
PMID: 23742252
The synthesis, preclinical profile, and in vivo efficacy in rat xenograft models of the novel and selective anaplastic lymphoma kinase inhibitor 15b (LDK378) are described. In this initial report, preliminary...
8.
Meister S, Plouffe D, Kuhen K, Bonamy G, Wu T, Barnes S, et al.
Science
. 2011 Nov;
334(6061):1372-7.
PMID: 22096101
Most malaria drug development focuses on parasite stages detected in red blood cells, even though, to achieve eradication, next-generation drugs active against both erythrocytic and exo-erythrocytic forms would be preferable....
9.
Richmond W, Wogan M, Isbell J, Gordon W
J Pharm Sci
. 2010 Sep;
99(11):4463-8.
PMID: 20845445
With the extensive use of different strains of mice and rats in in vivo efficacy models, lack of relevant metabolic clearance data among strains has been a concern. Metabolic clearance...
10.
Choi H, Wang Z, Richmond W, He X, Yang K, Jiang T, et al.
Bioorg Med Chem Lett
. 2006 Mar;
16(10):2689-92.
PMID: 16524731
A series of 2-amino-9-aryl-7H-pyrrolo[2,3-d]pyrimidines were designed and synthesized as focal adhesion kinase (FAK) inhibitors using molecular modeling in conjunction with a co-crystal structure. Chemistry was developed to introduce functionality onto...