Wendy B Macklin
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Explore the profile of Wendy B Macklin including associated specialties, affiliations and a list of published articles.
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104
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4828
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Recent Articles
1.
Pierce S, Jacobelli J, Given K, Macklin W, Gopinath J, Siemens M, et al.
Neurophotonics
. 2024 Jun;
11(3):034311.
PMID: 38867758
Significance: Stimulated emission depletion (STED) is a powerful super-resolution microscopy technique that can be used for imaging live cells. However, the high STED laser powers can cause significant photobleaching and...
2.
Owens G, Fellin T, Matschulat A, Salas V, Schaller K, Given K, et al.
J Clin Invest
. 2023 Aug;
133(19).
PMID: 37561592
B cell clonal expansion and cerebrospinal fluid (CSF) oligoclonal IgG bands are established features of the immune response in multiple sclerosis (MS). Clone-specific recombinant monoclonal IgG1 Abs (rAbs) derived from...
3.
Almeida A, Macklin W
Elife
. 2023 Apr;
12.
PMID: 37078701
Oligodendrocytes in the central nervous system exhibit significant variability in the number of myelin sheaths that are supported by each cell, ranging from 1 to 50 (1-8). Myelin production during...
4.
Frazier A, Mitchell D, Given K, Hunn G, Burch A, Childs C, et al.
Glia
. 2023 Feb;
71(6):1429-1450.
PMID: 36794545
Neonatal stroke is common and causes life-long motor and cognitive sequelae. Because neonates with stroke are not diagnosed until days-months after the injury, chronic targets for repair are needed. We...
5.
Jewett C, McCurdy B, OToole E, Stemm-Wolf A, Given K, Lin C, et al.
Elife
. 2023 Jan;
12.
PMID: 36656118
Trisomy 21, the genetic cause of Down syndrome, disrupts primary cilia formation and function, in part through elevated Pericentrin, a centrosome protein encoded on chromosome 21. Yet how trisomy 21...
6.
Woods C, Flockton A, Wallace L, Keenan C, Macklin W, Sharkey K, et al.
Am J Physiol Gastrointest Liver Physiol
. 2022 Dec;
324(2):G115-G130.
PMID: 36511517
Proteolipid protein 1 (Plp1) is highly expressed in enteric glia, labeling cells throughout the mucosa, muscularis, and the extrinsic innervation. Plp1 is a major constituent of myelin in the central...
7.
Dahl K, Almeida A, Hathaway H, Bourne J, Brown T, Finseth L, et al.
J Neurosci
. 2022 Dec;
43(4):540-558.
PMID: 36460463
In the CNS, oligodendrocyte progenitor cells (OPCs) differentiate into mature oligodendrocytes to generate myelin, an essential component for normal nervous system function. OPC differentiation is driven by signaling pathways, such...
8.
Khandker L, Jeffries M, Chang Y, Mather M, Evangelou A, Bourne J, et al.
Cell Rep
. 2022 Mar;
38(9):110423.
PMID: 35235799
Brain and spinal cord oligodendroglia have distinct functional characteristics, and cell-autonomous loss of individual genes can result in different regional phenotypes. However, a molecular basis for these distinctions is unknown....
9.
Benardais K, Ornelas I, Fauveau M, Brown T, Finseth L, Panic R, et al.
Brain Commun
. 2022 Feb;
4(1):fcac025.
PMID: 35224490
The p70 ribosomal S6 kinases (p70 ribosomal S6 kinase 1 and p70 ribosomal S6 kinase 2) are downstream targets of the mechanistic target of rapamycin signalling pathway. p70 ribosomal S6...
10.
George N, Gentile Polese A, Merle L, Macklin W, Restrepo D
J Neurosci
. 2022 Jan;
42(8):1491-1509.
PMID: 35022219
The axon initial segment (AIS), nodes of Ranvier, and the oligodendrocyte-derived myelin sheath have significant influence on the firing patterns of neurons and the faithful, coordinated transmission of action potentials...