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Wen-Chih Chiang

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Articles 67
Citations 1709
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Recent Articles
1.
Chou Y, Lai T, Lin Y, Chiang W, Chu T, Lin S, et al.
Nephron . 2023 Jan; 147(6):329-336. PMID: 36649699
Introduction: Old age has been considered as a positive modifier of chronic kidney disease (CKD), but the progression of CKD is often accelerated by acute kidney injury (AKI) in older...
2.
Chen Y, Yang C, Tsai C, Ang M, Chou S, Chiang W, et al.
J Int Med Res . 2022 Oct; 50(10):3000605221129674. PMID: 36262058
Newly-diagnosed or relapses of immunoglobulin A nephropathy (IgAN) have been associated with COVID-19 vaccination in the literature. Most reported cases were mild clinical diseases characterized by microscopic haematuria and do...
3.
Chang F, Liu C, Luo A, Huang T, Tsai M, Chen Y, et al.
Kidney Int . 2022 Aug; 102(4):780-797. PMID: 35934136
Plasma levels of angiopoietin-2 are increased in patients with chronic kidney disease (CKD). Moreover, mouse models of progressive kidney disease also demonstrate increased angiopoietin-2 in both plasmas and kidneys. The...
4.
Juan Y, Chiang W, Lin W, Yang C, Chou S, Hung R, et al.
J Clin Med . 2022 Jul; 11(14). PMID: 35887995
Our prior study indicates a close relationship between alternative complement pathway activation, galactose-deficient IgA1 (Gd-IgA1) concentration and clinical severity of IgA nephropathy (IgAN). Nonetheless, the relationship between complement factors and...
5.
Shih H, Pan S, Wu C, Chou Y, Chen C, Chang F, et al.
J Biomed Sci . 2021 Nov; 28(1):73. PMID: 34724959
Background: Renal erythropoietin (EPO)-producing (REP) cells produce EPO through hypoxia-inducible factor (HIF) 2α-activated gene transcription. Insufficient EPO production leads to anemia in patients with chronic kidney disease. Although recombinant EPO...
6.
Chiu Y, Lin W, Shu K, Fang Y, Chang F, Chou Y, et al.
Front Immunol . 2021 Jun; 12:638309. PMID: 34177889
Background: Galactose-deficient IgA (Gd-IgA) and alternative complement pathway activation are considered to be involved in the pathogenesis of IgA nephropathy (IgAN). Nevertheless, the relationships between alternative pathway activation and disease...
7.
Chang F, Lee M, Chiang C, Liu J, Lai T, Chiang W, et al.
J Formos Med Assoc . 2021 May; 120(12):2113-2119. PMID: 34039500
Backgrounds: Metabolic syndrome is a subclinical status in promoting atherosclerotic cardiovascular disease and type 2 diabetes mellitus. The significance of metabolic syndrome and pathophysiology in chronic kidney disease is not...
8.
Pan S, Tsai P, Chou Y, Chang Y, Chang F, Chiu Y, et al.
Kidney Int . 2021 Apr; 99(6):1354-1368. PMID: 33812664
Prolyl hydroxylase domain enzyme (PHD) inhibitors are effective in the treatment of chronic kidney disease (CKD)-associated anemia by stabilizing hypoxia inducible factor (HIF), thereby increasing erythropoietin and consequently erythropoiesis. However,...
9.
Chang F, Chen T, Huang T, Lin W, Liu J, Chiang W, et al.
J Formos Med Assoc . 2021 Feb; 121(1 Pt 1):152-161. PMID: 33640191
Background: The frontier of onco-nephrology, particularly renal complications of cancer and treatment, remains unexplored. We revisit the fundamental tool of diagnosing kidney disease, renal biopsy, in cancer patients with renal...
10.
Chen Y, Jhao P, Hung C, Wu Y, Lin S, Chiang W, et al.
J Clin Invest . 2021 Jan; 131(5). PMID: 33465051
Renal fibrosis, a common pathological manifestation of virtually all types of chronic kidney disease (CKD), often results in diffuse kidney scarring and predisposes to end-stage renal disease. Currently, there is...