Weizheng Xu
Overview
Explore the profile of Weizheng Xu including associated specialties, affiliations and a list of published articles.
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Articles
22
Citations
525
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Recent Articles
11.
Obrosova I, Xu W, Lyzogubov V, Ilnytska O, Mashtalir N, Vareniuk I, et al.
Free Radic Biol Med
. 2007 Nov;
44(6):972-81.
PMID: 17976390
Evidence that poly(ADP-ribose) polymerase (PARP) activation plays an important role in diabetic complications is emerging. This study evaluated the role of PARP in rat and mouse models of advanced diabetic...
12.
Tentori L, Lacal P, Muzi A, Dorio A, Leonetti C, Scarsella M, et al.
Eur J Cancer
. 2007 Aug;
43(14):2124-33.
PMID: 17714938
Poly(ADP-ribose) polymerase (PARP)-1 has recently been shown to promote tumour progression. Since angiogenesis is an essential requirement for tumour growth, we examined whether PARP inhibition/deletion might affect endothelial cell functions....
13.
Wojewodzka M, Kruszewski M, Buraczewska I, Xu W, Massuda E, Zhang J, et al.
Acta Biochim Pol
. 2007 Feb;
54(1):63-9.
PMID: 17311110
Sirtuins (type III histone deacetylases) are an important member of a group of enzymes that modify chromatin conformation. We investigated the role of sirtuin inhibitor, GPI 19015, in double strand...
14.
Cuzzocrea S, Genovese T, Mazzon E, Crisafulli C, Min W, Di Paola R, et al.
J Pharmacol Exp Ther
. 2006 Jul;
319(1):127-38.
PMID: 16825529
The aim of the present study was to examine the role of poly-(ADP-ribose) glycohydrolase (PARG) on the modulation of the inflammatory response and tissue injury associated with neurotrauma. Spinal cord...
15.
Tentori L, Leonetti C, Scarsella M, Muzi A, Mazzon E, Vergati M, et al.
FASEB J
. 2006 Jul;
20(10):1709-11.
PMID: 16809434
Poly(ADP-ribose) polymerase (PARP) inhibitors enhance the antitumor activity of the topoisomerase I inhibitor irinotecan (CPT-11), which is used to treat advanced colorectal carcinoma. Since PARP inhibitors sensitize tumor cells also...
16.
Majer P, Hin B, Stoermer D, Adams J, Xu W, Duvall B, et al.
J Med Chem
. 2006 May;
49(10):2876-85.
PMID: 16686531
A series of thiol-based inhibitors containing a benzyl moiety at the P1' position have been synthesized and tested for their abilities to inhibit glutamate carboxypeptidase II (GCP II). 3-(2-Carboxy-5-mercaptopentyl)benzoic acid...
17.
Di Paola R, Mazzon E, Xu W, Genovese T, Ferrraris D, Muia C, et al.
Eur J Pharmacol
. 2005 Nov;
527(1-3):163-71.
PMID: 16310767
Poly (ADP-ribose) polymerase-1 (PARP-1), a nuclear enzyme activated by DNA strand breaks, plays a detrimental role during inflammation. As inflammation is important in the development of colitis and ischemia/reperfusion (I/R)...
18.
Cuzzocrea S, Di Paola R, Mazzon E, Cortes U, Genovese T, Muia C, et al.
FASEB J
. 2005 Mar;
19(6):558-66.
PMID: 15791006
Poly (ADP-ribosyl)ation, an early post-translational modification in response to DNA damage, is catalyzed by poly (ADP-ribose) polymerase (PARP-1) and catabolized by poly(ADP-ribose) glycohydrolase (PARG). The aim of this study was...
19.
Tentori L, Leonetti C, Scarsella M, Vergati M, Xu W, Calvin D, et al.
Int J Oncol
. 2005 Jan;
26(2):415-22.
PMID: 15645126
We previously demonstrated that intravenous or intra-cerebral administration of poly (ADP-ribose) polymerase-1 (PARP-1) inhibitors increases the antitumor activity of temozolomide (TMZ), an oral anticancer drug used for the treatment of...
20.
Genovese T, Di Paola R, Catalano P, Li J, Xu W, Massuda E, et al.
Crit Care Med
. 2004 Jun;
32(6):1365-74.
PMID: 15187521
Objective: Poly(ADP-ribose) is synthesized from nicotinamide adenine dinucleotide by poly(ADP-ribose) polymerase (PARP) and degraded by poly(ADP-ribose) glycohydrolase (PARG). The activation of the PARP/PARG pathway has been found in a variety...