Weixin Tang
Overview
Explore the profile of Weixin Tang including associated specialties, affiliations and a list of published articles.
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Articles
28
Citations
1424
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Recent Articles
11.
Rahman I, Sanchez A, Tang W, van der Donk W
ACS Infect Dis
. 2021 Jul;
7(8):2445-2454.
PMID: 34265205
Enterococcal cytolysin is a hemolytic virulence factor linked to human disease and increased patient mortality. Produced by pathogenic strains of , cytolysin is made up of two small, post-translationally modified...
12.
Bobeica S, Zhu L, Acedo J, Tang W, van der Donk W
Chem Sci
. 2021 Jun;
11(47):12871-12876.
PMID: 34101773
[This corrects the article DOI: 10.1039/D0SC01651A.].
13.
Bobeica S, Zhu L, Acedo J, Tang W, van der Donk W
Chem Sci
. 2021 Jun;
11(47):12854-12870.
PMID: 34094481
Lanthipeptides are characterized by thioether crosslinks formed by post-translational modifications. The cyclization process that favors a single ring pattern over many other possible ring patterns has been the topic of...
14.
Tang W, Bobeica S, Wang L, van der Donk W
J Ind Microbiol Biotechnol
. 2018 Nov;
46(3-4):537-549.
PMID: 30484123
CylA is a subtilisin-like protein belonging to a recently expanded serine protease family related to class II lanthipeptide biosynthesis. As a leader peptidase, CylA is responsible for maturation of the...
15.
Tang W, Dong S, Repka L, He C, Nair S, van der Donk W
Chem Sci
. 2018 Aug;
6(11):6270-6279.
PMID: 30090246
The final step of lanthipeptide biosynthesis involves the removal of leader peptides by dedicated proteases. characterization of LicP, a class II LanP protease involved in the biosynthesis of the lantibiotic...
16.
Hu J, Miller S, Geurts M, Tang W, Chen L, Sun N, et al.
Nature
. 2018 Mar;
556(7699):57-63.
PMID: 29512652
A key limitation of the use of the CRISPR-Cas9 system for genome editing and other applications is the requirement that a protospacer adjacent motif (PAM) be present at the target...
17.
Tang W, Liu D
Science
. 2018 Feb;
360(6385).
PMID: 29449507
We present two CRISPR-mediated analog multi-event recording apparatus (CAMERA) systems that use base editors and Cas9 nucleases to record cellular events in bacteria and mammalian cells. The devices record signal...
18.
Tang W, Hu J, Liu D
Nat Commun
. 2017 Jun;
8:15939.
PMID: 28656978
Programmable sequence-specific genome editing agents such as CRISPR-Cas9 have greatly advanced our ability to manipulate the human genome. Although canonical forms of genome-editing agents and programmable transcriptional regulators are constitutively...
19.
Tang W, Thibodeaux G, van der Donk W
ACS Chem Biol
. 2016 Jun;
11(9):2438-46.
PMID: 27348535
Stereochemical control is critical in natural product biosynthesis. For ribosomally synthesized and post-translationally modified peptides (RiPPs), the mechanism(s) by which stereoselectivity is achieved is still poorly understood. In this work,...
20.
Dong S, Tang W, Lukk T, Yu Y, Nair S, van der Donk W
Elife
. 2015 Jul;
4.
PMID: 26226635
The enterococcal cytolysin is a virulence factor consisting of two post-translationally modified peptides that synergistically kill human immune cells. Both peptides are made by CylM, a member of the LanM...